Web tool for estimating the cancer hazard rates in aging

Cancer Informatics
Tengiz MdzinarishviliSimon Sherman

Abstract

A computational approach for estimating the overall, population, and individual cancer hazard rates was developed. The population rates characterize a risk of getting cancer of a specific site/type, occurring within an age-specific group of individuals from a specified population during a distinct time period. The individual rates characterize an analogous risk but only for the individuals susceptible to cancer. The approach uses a novel regularization and anchoring technique to solve an identifiability problem that occurs while determining the age, period, and cohort (APC) effects. These effects are used to estimate the overall rate, and to estimate the population and individual cancer hazard rates. To estimate the APC effects, as well as the population and individual rates, a new web-based computing tool, called the CancerHazard@Age, was developed. The tool uses data on the past and current history of cancer incidences collected during a long time period from the surveillance databases. The utility of the tool was demonstrated using data on the female lung cancers diagnosed during 1975-2009 in nine geographic areas within the USA. The developed tool can be applied equally well to process data on other cancer sites. The data o...Continue Reading

References

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Nov 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·E Georg Luebeck, Suresh H Moolgavkar
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rafael MezaE Georg Luebeck
Mar 19, 2009·Cancer Causes & Control : CCC·Suresh H MoolgavkarJay Turim
May 26, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Philip S Rosenberg, William F Anderson
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Aug 26, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Philip S RosenbergWilliam F Anderson

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Citations

Oct 16, 2015·PloS One·Simon ShermanTengiz Mdzinarishvili

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Software Mentioned

Age
JAMA
CancerHazard
SEER
@ Age
JFreeChart
Stat
AgePeriodCohort
Excel

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