Weekend effect in acute coronary syndrome: A meta-analysis of observational studies

European Heart Journal. Acute Cardiovascular Care
Chun Shing KwokMamas A Mamas

Abstract

The effect of a weekend compared with a weekday hospital admission on patient outcomes after an acute coronary syndrome is unclear. This study aims to determine whether collectively there is a weekend effect in acute coronary syndrome. We conducted a systematic review and meta-analysis of cohort studies examining the association between weekend compared to weekday admission at any time of the day and early mortality (in-hospital or 30-day). A search was performed on Medline and Embase and relevant studies were pooled using random effects meta-analysis for risk of early mortality. Additional analyses were performed considering only more recent studies (conducted after 2005) and by patient group (ST-elevation myocardial infarction [STEMI] or non-STEMI [NSTEMI]), as well as meta-regression according to starting year and mean year of study. A total of 18 studies were included with over 14 million participants incorporating 3 million weekend and over 11.5 million weekday admissions and the rates of mortality were 19.2% and 23.4%, respectively. The pooled results of all 18 studies suggest that weekend admission was associated with a small increased risk of early mortality (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.03-1.09)...Continue Reading

References

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Citations

Jan 31, 2019·European Heart Journal·Shmuel Chen, Gregg W Stone
Aug 9, 2019·European Heart Journal. Acute Cardiovascular Care·Christiaan Jm Vrints
May 1, 2020·Annals of the American Thoracic Society·Otavio T RanzaniLuciano Cesar Pontes Azevedo
May 31, 2019·Journal of Vascular Surgery·George GalyfosKonstantinos Filis

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