Weekly cis-diamminedichloroplatinum II as induction chemotherapy in recurrent carcinoma of the cervix

Gynecologic Oncology
M S PiverM Maniccia

Abstract

Twenty-four evaluable patients with recurrent carcinoma of the cervix after previous pelvic irradiation were treated with cis-diamminedichloroplatinum II (cis-DDP). Of the 14 patients who received low-dose (1 mg/kg) weekly induction cis-DDP, 10 (71%) responded, 6 (43%) of which were complete responses. Four (40%) of the ten patients who received high-dose (100 mg/m2) monthly cis-DDP responded, two of which were complete responses. Maintenance of these responses by combination chemotherapy which includes cis-DDP remains a significant problem.

Citations

Jan 1, 1991·Cancer Chemotherapy and Pharmacology·E JunorR P Symonds
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Aug 4, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C NyongesaJ Kotzen
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