Weekly enhanced T1-weighted MRI with Gadobutrol injections in MS patients: Is there a signal intensity increase in the dentate nucleus and the globus pallidus?

European Journal of Radiology
Paul JaulentFrancois Cotton

Abstract

Gadolinium-based contrast agents (GBCAs) administration have drastically improved the accuracy of Multiple Sclerosis (MS) diagnosis by highlighting any damage to the brain blood barrier, thereby differentiating between active and non-active lesions. Following multiple administrations of GBCAs, several MS studies have reported a signal intensity (SI) increase on unenhanced T1-weighted images in certain brain regions such as the dentate nucleus (DN) and the globus pallidus (GP). Our aim was therefore to determine the accumulation of macrocyclic GBCAs on enhanced T1-weighted images SI in the DN and the GP of MS patients injected eight times. Five MS patients underwent eight weekly consecutive MRI scans. Enhanced 3D T1-weighted images with Gadobutrol as a macrocyclic GBCA, were acquired. A ROI-based approach was applied for the evaluation of SI in the DN to middle cerebellar peduncle (DN-MCP) and GP to semi-oval white matter (GP-SOWM) ratios. An analysis of variance on repeated measures was used for the statistical analysis of each ratio. No DN-MCP and GP-SOWM SI ratio differences were observed over the eight-weeks period using the macrocyclic GBCA. Iterative and weekly injections of macrocyclic GBCAs are not associated with T1 sig...Continue Reading

References

Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Nov 13, 2008·Investigative Radiology·Thomas FrenzelHanns-Joachim Weinmann
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Apr 16, 2011·AJNR. American Journal of Neuroradiology·M AbsintaM Filippi
Sep 27, 2012·Multiple Sclerosis : Clinical and Laboratory Research·M P SormaniN De Stefano
Oct 11, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zhuxian Zhou, Zheng-Rong Lu
Mar 6, 2015·Radiology·Robert J McDonaldLaurence J Eckel
Aug 22, 2015·AJNR. American Journal of Neuroradiology·M E AdinD M Yousem
Jan 27, 2016·Journal of the American College of Radiology : JACR·Ashkan A MalayeriDavid A Bluemke
Sep 30, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Ludwig SchlemmMichael Scheel
Dec 3, 2017·Acta Neuropathologica Communications·Stefan A BerghoffGesine Saher

❮ Previous
Next ❯

Citations

Mar 1, 2019·International Journal of Molecular Sciences·Alessandro Fulgenzi, Maria Elena Ferrero
Jul 3, 2020·Journal of Neuroradiology. Journal De Neuroradiologie·François LersyStéphane Kremer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.