Weekly low-dose docetaxel for salvage chemotherapy in pretreated elderly or poor performance status patients with non-small cell lung cancer.

Journal of Korean Medical Science
Keun-Wook LeeJong Seok Lee

Abstract

Although docetaxel monotherapy has shown clinical benefits for previously treated patients with advanced non-small cell lung cancer (NSCLC), the efficacy of salvage docetaxel chemotherapy for elderly patients or patients with poor performance status (PS) is controversial. Therefore, we conducted a phase II trial to evaluate the safety and efficacy of weekly low-dose docetaxel monotherapy in these patients. Forty NSCLC patients, who had been previously treated with one or more chemotherapy regimens, received docetaxel at a dose of 25 mg/m(2) weekly on days 1, 8, and 15 of a 28-day cycle. All patients were >or=65 yr or had a PS of grade 2 in the cases of <65 yr. Weekly low-dose docetaxel was well-tolerated. Grade 3/4 non-hematologic toxicities were rare; fatigue in 3 patients (8%), anorexia in 3 patients (8%) and stomatitis in 2 patients (5%). Grade 3/4 neutropenia was noted in only one patient (3%). By intent-to-treat analysis, nine patients (23%) had partial responses and eleven patients (28%) demonstrated stable disease. The median progression-free survival and overall survival were 9.9 weeks and 37.7 weeks, respectively. Weekly low-dose docetaxel therapy provides a reasonable alternative for NSCLC salvage treatment in pretrea...Continue Reading

References

Dec 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M Hryniuk, M Goodyear
Mar 1, 1989·Controlled Clinical Trials·R Simon
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J D HainsworthF A Greco
May 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ShepherdJ Berille
Jul 10, 2001·Acta Oncologica·S SörensonUNKNOWN SBU-group. Swedish Council of Technology Assessment in Health Care
Oct 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Akira InoueNagahiro Saijo
Dec 25, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roberto PetrioliGuido Francini
Dec 24, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David G PfisterUNKNOWN American Society of Clinical Oncology
Dec 16, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R GervaisE Quoix
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cesare GridelliCorey Langer
Nov 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang SchuetteMonika Serke
Dec 24, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C CampsUNKNOWN Spanish Lung Cancer Group
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arti HurriaClifford Hudis
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rogerio LilenbaumHongyan Du
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo Di MaioCesare Gridelli
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Miriam B Rodin, Supriya G Mohile
Oct 18, 2007·The Korean Journal of Internal Medicine·Yoon Ho KoJin Hyoung Kang
Dec 1, 2005·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hai-Rim ShinUNKNOWN Members of the Regional Cancer Registries

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