Weekly Paclitaxel after failure of gemcitabine in pancreatic cancer patients with malignant ascites: a retrospective study

Japanese Journal of Clinical Oncology
Takehito ShukuyaNozomu Machida

Abstract

Peritoneal metastasis is one of the major sites of disease progression of pancreatic cancer. There have been few trials in the second-line setting after gemcitabine failure because patients can hardly be candidates for chemotherapy after failure in the first-line chemotherapy, especially those with malignant ascites. The safety and efficacy of weekly paclitaxel therapy was evaluated for pancreatic cancer patients with malignant ascites in this retrospective study. The subjects of this retrospective study were 23 advanced pancreatic cancer patients with malignant ascites who received weekly paclitaxel therapy after gemcitabine failure. Paclitaxel (80 mg/m(2), div. for 1 h) was administered on Days 1, 8 and 15, every 4 weeks. While the disease control rate was 35%, decrease of ascites was obtained in 30% of the patients and ascites control rate was 61%. The median survival time was 101 days. Toxicities were mild, although one treatment-related death occurred. Weekly paclitaxel therapy may be useful treatment option for pancreatic cancer patients with malignant ascites after gemcitabine failure.

References

Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Mar 29, 2005·The Oncologist·Howard A BurrisArthur Staddon
Mar 25, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Shuichi HironakaYusuke Onozawa
Apr 25, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm J MooreUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Oct 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David CunninghamJohn P Neoptolemos

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Citations

Oct 30, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Hüseyin EnginYücel Ustündağ
Oct 26, 2016·Cancer Chemotherapy and Pharmacology·Radmila LemstrovaBeatrice Mohelnikova-Duchonova
May 23, 2017·Molecular and Clinical Oncology·Hidehiro TajimaHiroyuki Nakamura
Aug 7, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wen Wee Ma, Manuel Hidalgo

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