PMID: 11605177Oct 18, 2001Paper

Weekly paclitaxel in advanced non-small cell lung cancer

Seminars in Oncology
A Y ChangL F Hui

Abstract

Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) is one of the most commonly used agents in treating patients with locally advanced and metastatic non-small cell lung cancer (NSCLC). It is usually given once every 3 weeks. We have evaluated paclitaxel given once per week for 3 weeks every 4 weeks for patients with recurrent or metastatic NSCLC. Two consecutive studies using weekly paclitaxel were performed. The first study was a dose-escalation study with paclitaxel beginning at 50 mg/m(2) days 1, 8, and 15 every 4 weeks. Subsequent dose escalation was performed with 10 mg/m(2) increments per week. The second phase II study used paclitaxel at 80 mg/m(2) days 1, 8, and 15 every 4 weeks. The phase I study showed that the maximum tolerated dose was 90 mg/m(2)/wk for 3 weeks with 1 week off. The efficacy and side effects of both phase I and II were quite similar; therefore, the results were combined. Seventeen patients were in the phase I and 30 patients in the phase II study. The mean age was 72 years. Twenty-three patients had Eastern Cooperative Oncology Group performance status of 2 and 16 patients had received prior chemotherapy. One complete and 13 partial responses were observed with response duration ranging ...Continue Reading

Citations

Apr 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Giovanni Luca CeresoliEugenio Villa
Oct 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristina FonsecaRogério Gaspar
Jul 23, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sang-We KimJung Sin Lee
Dec 31, 2002·Critical Reviews in Oncology/hematology·Vicente AlberolaOscar Juan
Dec 31, 2002·Critical Reviews in Oncology/hematology·Paolo MarchettiCorrado Ficorella
Apr 23, 2010·Chemical Communications : Chem Comm·Zhong CaoJunichi Kikuchi
Jul 20, 2002·Current Opinion in Oncology·Louise Medley, Michael Cullen
Sep 27, 2012·International Journal of Clinical Oncology·Patricia M M B SoetekouwVivianne C G Tjan-Heijnen
Nov 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang SchuetteMonika Serke
Sep 22, 2020·Expert Opinion on Drug Delivery·Archana UpadhyaAmbikanandan Misra
Oct 18, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C P BelaniC K Obasaju
Aug 18, 2016·Bioconjugate Chemistry·Min ZhaoXingjie Guo

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