Weekly vinorelbine and docetaxel as second-line chemotherapy for pretreated non-small cell lung cancer patients: a phase I-II trial

Journal of Chemotherapy
F NelliE Cortesi

Abstract

Docetaxel was proven to be effective as second-line therapy for patients with advanced NSCLC after failure of platinum-based front-line chemotherapy. We designed this phase I/II study to define the Maximum Tolerated Dose of weekly docetaxel combined with weekly vinorelbine, and subsequently evaluate tolerability and activity of this schedule in NSCLC patients who were progressive after treatment with either cisplatin and gemcitabine or carboplatin and paclitaxel regimens. To be eligible for the study, patients were required to have a WHO performance status < or =2, failure after at least two cycles of first platinum-based chemotherapy, and no prior treatment with docetaxel and vinorelbine. A total of 27 patients were enrolled in this phase I/II study. A weekly docetaxel dose of 25 mg/m2 was recommended in combination with fixed vinorelbine dose of 20 mg/m2, and 24 patients were treated at this dose level. Severe neutropenia (62%) and febrile neutropenia (29%) were the most frequent toxicities, with 83% of patients requiring dose modification or delay. In the phase II study, 5 (21%) patients obtained a partial response, 8 (33%) patients had stable disease, whereas 10 (42%) patients progressed. After a median follow-up of 18.7 mo...Continue Reading

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Citations

Dec 20, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Fabrice BarlésiJean-Louis Pujol
Nov 17, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Thomas WibmerStefan Krüger
Oct 19, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Corey J LangerNick Thatcher
Jan 14, 2010·Cancer Chemotherapy and Pharmacology·Kazuhiro YanagiharaMasanori Fukushima
Mar 24, 2006·Cancer Chemotherapy and Pharmacology·J FeliuM Gonzalez-Barón
Oct 4, 2012·British Journal of Cancer·K KomiyamaUNKNOWN Kanto Respiratory Disease Study Group
Oct 15, 2008·Molecular Cancer Therapeutics·Richard F RiedelPhillip G Febbo

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