Wegener's granulomatosis: clinical manifestations, differential diagnosis, and management of ocular and systemic disease

Survey of Ophthalmology
Ahmad B TarabishyGary S Hoffman

Abstract

Wegener's granulomatosis (WG) is a systemic inflammatory disease whose histopathologic features often include necrosis, granuloma formation, and vasculitis of small-to-medium-sized vessels. WG involves many interrelated pathogenic pathways that are genetic, cell-mediated, neutrophil-mediated, humoral, and environmental. WG most commonly involves the upper respiratory tract, lungs, and kidneys, but has been reported to affect almost any organ. Ophthalmologic involvement is an important cause of morbidity in WG patients, occurring in approximately one-half of patients. The presence of unexplained orbital inflammatory disease, scleritis, peripheral ulcerative keratitis, cicatricial conjunctivitis, nasolacrimal duct stenosis, retinal vascular occlusion, or infrequently uveitis should raise the question of possible WG. A thorough clinical examination, laboratory testing, radiologic imaging, and histologic examination are essential to diagnosing WG and excluding potential mimics. Previously a uniformly fatal disease, treatment with cytotoxic and immunosuppressive agents has greatly improved survival. Treatment-related morbidity is a serious limitation of conventional therapies, leading to numerous ongoing studies of alternative agents.

References

Mar 15, 1992·Annals of Internal Medicine·G S HoffmanA S Fauci
Nov 1, 1991·Cornea·J A Leavitt, S I Butrus
Apr 1, 1990·Archives of Ophthalmology·T W Samuelson, C E Margo
Jan 20, 1972·The New England Journal of Medicine·A LoredoL Murillo
Jan 1, 1984·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·J François
Mar 1, 1983·Ophthalmology·C L BullenR A DeRemee
Oct 1, 1980·Archives of Ophthalmology·H W Skalka, J T Prchal
May 1, 1995·The British Journal of Ophthalmology·A B TulloJ L Noble
Apr 1, 1996·AJR. American Journal of Roentgenology·J M ProvenzaleA W Weber
May 1, 1997·Journal of Computer Assisted Tomography·N A CourcoutsakisN J Patronas
Apr 21, 1998·Survey of Ophthalmology·L E Harman, C E Margo
Sep 29, 1998·Arthritis and Rheumatism·G S Hoffman, U Specks
May 26, 1999·Survey of Ophthalmology·E M Messmer, C S Foster
Jun 22, 1999·Thorax·C A Langford, G S Hoffman
Feb 24, 2000·The British Journal of Ophthalmology·A S Kwan, G E Rose
Oct 12, 2000·American Journal of Ophthalmology·D A JabsM J Marsh
May 16, 2001·The British Journal of Ophthalmology·F M MeierW Bernauer
Sep 6, 2001·Ophthalmology·T L WooUNKNOWN Australasian Orbital and Adnexal Wagener's Study Group
Dec 4, 2001·American Journal of Ophthalmology·M KameiS Kinoshita
Jan 5, 2002·American Journal of Ophthalmology·Tomohiro IidaJeff Kantor
May 29, 2002·Eye·M Niskopoulou, N Du Toit
Jul 20, 2002·Cornea·Aaron C Fortney, James Chodosh
Aug 6, 2002·Controlled Clinical Trials·UNKNOWN WGET Research Group
Dec 31, 2002·Investigative Ophthalmology & Visual Science·David StempelLynn K Gordon
Jul 4, 2003·The New England Journal of Medicine·David JayneUNKNOWN European Vasculitis Study Group
Sep 18, 2003·Ophthalmology·Michael R RobinsonJanine A Smith
Sep 10, 1960·JAMA : the Journal of the American Medical Association·R L BLACKJ J BUNIM
Nov 19, 2003·European Journal of Ophthalmology·P VenkateshH K Tewari
Mar 17, 2004·Ophthalmology·Robert HaimoviciUNKNOWN Central Serous Chorioretinopathy Case-Control Study Group
May 29, 2004·Ophthalmic Plastic and Reconstructive Surgery·Ramon C GhanemSuzana Matayoshi

❮ Previous
Next ❯

Citations

Feb 4, 2014·Journal of Autoimmunity·Pamela M K Lutalo, David P D'Cruz
Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Kathleen T Montone
Dec 10, 2013·Reumatología clinica·Ruth López-GonzálezJuan Pablo Valdazo de Diego
Jun 2, 2012·Clinical Ophthalmology·Ayse Yagci
Sep 12, 2013·BMC Research Notes·Juliane MatlachWinfried Göbel
Jul 6, 2014·Current Eye Research·Hatice Nida SenDebra A Goldstein
Feb 3, 2016·Head and Neck Pathology·Timothy R Helliwell
May 8, 2015·Case Reports in Rheumatology·Taro MasudaKiyosi Migita
Dec 1, 2015·Archives of Pathology & Laboratory Medicine·Kathleen T Montone
May 20, 2016·Intractable & Rare Diseases Research·Buraa KubaisiC Stephen Foster
Nov 21, 2015·AJR. American Journal of Roentgenology·Marius G PakalniskisWendy R K Smoker
Jan 30, 2015·Journal of Ophthalmic Inflammation and Infection·Roxana UrseaChi-Chao Chan
Oct 18, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yumiko MatsubaAndreas Knopf
Dec 21, 2012·Ocular Immunology and Inflammation·Bing JiangShi-hui Wei
May 18, 2016·World Journal of Surgical Oncology·Victoria BîrluţiuIoan Sorin Zaharie
Aug 7, 2010·Rheumatic Diseases Clinics of North America·Allan S Wiik
Aug 9, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Philippe LefrançoisMartin Desrosiers
Apr 21, 2016·Ophthalmic Plastic and Reconstructive Surgery·Stephanie M YoungAudrey L G Looi
Dec 23, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Amanda Agyemang, Anna Nowak-Wegrzyn
Feb 6, 2017·Surgical Pathology Clinics·Kathleen T Montone, Virginia A LiVolsi
May 11, 2017·BMJ Case Reports·Max J BlumbergSangita P Patel
Jul 10, 2013·Orvosi hetilap·Klára GadóGyula Domján
Sep 8, 2012·International Ophthalmology Clinics·Swetangi D Bhaleeya, Janet Davis
May 3, 2018·Journal of Ophthalmic & Vision Research·Ali SalehiElnaz Pirmoazzen
Sep 2, 2017·Zeitschrift für Rheumatologie·I KötterC Deuter
Sep 6, 2019·Current Rheumatology Reports·Gabriela M Espinoza, Jessica L Liu
Nov 6, 2014·Retinal Cases & Brief Reports·Saloomeh Saati, Srinivas R Sadda
Apr 27, 2016·Ophthalmic Plastic and Reconstructive Surgery·Archana SrinivasanJurij R Bilyk
Nov 19, 2015·Retinal Cases & Brief Reports·Rasanamar K SandhuDonna H Kim
Sep 11, 2018·Journal of Current Ophthalmology·Mahmoud NejabatMohammad Hassan Jalalpour
Feb 18, 2017·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Abdullah M Alfawaz
Nov 15, 2015·The British Journal of Ophthalmology·Lidia CochoC Stephen Foster
Mar 16, 2019·Ophthalmology and Therapy·Evdokia SfiniadakiIrini Chatziralli
Nov 21, 2019·European Journal of Ophthalmology·Manon ClémentPierre Lebranchu
Jan 10, 2013·International Journal of Immunopathology and Pharmacology·A SorianoA Afeltra
Jan 11, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hanan A AlmouhawisStephen R Porter
Oct 16, 2019·Korean Journal of Ophthalmology : KJO·Dong Yoon KimJin Young Kim
Mar 14, 2020·Orbit·Adriana Davila-CamargoÁngel Nava-Castañeda
Sep 18, 2015·Veterinary Sciences·Guillaume Cazalot, Sidonie N Lavergne
May 7, 2014·Ophthalmic Plastic and Reconstructive Surgery·Kwesi Nyan Amissah-ArthurSoupramanien Sandramouli
Mar 30, 2019·Archives of Dermatological Research·Luis J BordaAlex G Ortega-Loayza
Apr 14, 2020·Ophthalmic Plastic and Reconstructive Surgery·Bobak BahramiDinesh Selva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.