PMID: 9548575Apr 21, 1998Paper

Wegener's granulomatosis

Survey of Ophthalmology
L E Harman, C E Margo

Abstract

Clinical manifestations of Wegener's granulomatosis are nonspecific and indistinguishable from a variety of neoplastic, infectious, and inflammatory diseases. Ophthalmic disease is the presenting feature in nearly one sixth of patients with Wegener's granulomatosis and will ultimately develop in a majority. The discovery of antineutrophil cytoplasmic antibodies, particularly antiproteinase-3, has changed the clinical approach to evaluating patients suspected of having Wegener's granulomatosis. These antibodies are distinguished from other related autoantibodies because they produce a coarse granular pattern of cytoplasmic staining on indirect immunofluorescence with ethanol-fixed neutrophils. Treatment of Wegener's granulomatosis with oral cyclophosphamide and corticosteroids has decreased morbidity and improved survival, but side effects from long-term immunosuppressive therapy are common and sometimes serious. The effectiveness of trimethoprim-sulfamethoxazole in decreasing the number and severity of recurrences of Wegener's granulomatosis is being investigated. It remains to be determined if wide use of trimethoprim-sulfamethoxazole in limited Wegener's granulomatosis could further improve the quality of life for some patients.

References

Jan 1, 1976·Medicine·J DuffyK W Min
Jan 1, 1976·Medicine·L Axelrod
Oct 1, 1975·Postgraduate Medicine·R D deShazo
Mar 1, 1978·American Journal of Ophthalmology·P AustinH T Kleinfelter
Sep 1, 1979·International Journal of Dermatology·N A Soter, S I Wasserman
May 1, 1978·The American Journal of Medicine·A S Fauci
Aug 1, 1978·American Journal of Ophthalmology·L M JampolM F Goldberg
Oct 1, 1978·Archives of Ophthalmology·R M ChavisJ E Wright
Nov 30, 1978·The New England Journal of Medicine·J M FoidartS I Katz
Dec 1, 1975·The Journal of Urology·F BerglundR Pompeius
Nov 19, 1992·The New England Journal of Medicine·V AgnelloL M Kaplan
Nov 1, 1992·Arthritis and Rheumatism·G S HoffmanA S Fauci
Dec 1, 1992·Clinical and Experimental Immunology·B A van de WielR Goldschmeding
Jun 15, 1992·American Journal of Ophthalmology·C E MargoL M Hamed
Feb 1, 1991·Immunology Today·C G KallenbergJ J Weening
Jun 8, 1991·Lancet·W H SchmittW L Gross
Mar 15, 1992·Annals of Internal Medicine·G S HoffmanA S Fauci
Nov 1, 1991·The British Journal of Ophthalmology·A D PearsonJ M Howe
Apr 1, 1991·Journal of the American Academy of Dermatology·A PatelD N Sauder
Jul 1, 1991·Journal of the American Academy of Dermatology·S J CohenW P Su
Jun 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J C Jennette, R J Falk
Feb 1, 1991·Human Pathology·E A Del Buono, A Flint
Apr 1, 1991·The American Journal of Surgical Pathology·W D TravisA S Fauci
Apr 15, 1991·American Journal of Ophthalmology·R D SacksR B O'Grady
Apr 1, 1991·British Journal of Rheumatology·E M HayP J Holt
Aug 1, 1990·Arthritis and Rheumatism·J W TervaertG K van der Hem
Aug 1, 1990·The Journal of Allergy and Clinical Immunology·A SaxonS Targan

❮ Previous
Next ❯

Citations

Jan 13, 2004·Eye·N G ZiakasN S Georgiadis
Mar 10, 2005·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Fiona CostelloBrian Leonard
Jan 19, 2006·Ophthalmic Plastic and Reconstructive Surgery·David R JordanHamidreza Faraji
Feb 3, 2006·Clinical & Experimental Ophthalmology·Tze'Yo TohBrendan J Vote
May 5, 2009·Ocular Immunology and Inflammation·Grace Levy-ClarkeChi-Chao Chan
May 12, 2010·Cornea·Valentín HuervaAgustín Ruiz
Jan 30, 2015·Journal of Ophthalmic Inflammation and Infection·Roxana UrseaChi-Chao Chan
Nov 30, 2018·The Annals of Otology, Rhinology, and Laryngology·Ronald SahyouniHamid R Djalilian
May 8, 2010·Clinical & Experimental Ophthalmology·Georgina C ClarkGerard Sutton
Jul 8, 2008·Clinical Rheumatology·John A Vischio, Christine T McCrary
May 23, 2014·Acta Ophthalmologica·Christos ChristakopoulosJon Peiter Saunte
Jun 5, 2003·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Kimberly P CockerhamAhmed A Hidayat
Jan 18, 2006·Eye·D J de SilvaJ M Olver
Jan 1, 2009·Journal of Ocular Biology, Diseases, and Informatics·Angela S WatkinsJustine R Smith
Jan 1, 2007·Retinal Cases & Brief Reports·Kenichiro BesshoWilliam R Freeman
Jun 17, 2016·Retinal Cases & Brief Reports·Lik Thai LimRamana Moorthy
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Petros Aristodemou, Miles Stanford
Sep 24, 2009·Rheumatology International·Nathan CantoniThomas Daikeler
Nov 19, 2015·Retinal Cases & Brief Reports·Rasanamar K SandhuDonna H Kim
Jul 13, 2002·European Journal of Ophthalmology·M SoheilianM Aletaha
Nov 19, 2003·European Journal of Ophthalmology·P VenkateshH K Tewari
Jun 5, 2002·Orbit·Christophe Valmaggia, Jörg Neuweiler
Jun 14, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·B M Stoffelns
Jul 7, 2018·Allergy & Rhinology·James A GalloglyJoseph D Brunworth
Mar 13, 2014·Ophthalmic Plastic and Reconstructive Surgery·Rachel K SobelRichard C Allen
Dec 15, 2018·Korean Journal of Ophthalmology : KJO·Kyu Young ShimYu Cheol Kim
Apr 14, 2020·Ophthalmic Plastic and Reconstructive Surgery·Bobak BahramiDinesh Selva
Jun 8, 2007·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Gul ArikanAli Kupelioglu
Sep 6, 2001·Ophthalmology·T L WooUNKNOWN Australasian Orbital and Adnexal Wagener's Study Group
Dec 14, 2004·Lancet·Peter McCluskey, Richard J Powell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.