Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation

Translation
Felicity Z WattsSimon J Morley

Abstract

Regulation of protein synthesis is of fundamental importance to cells. It has a critical role in the control of gene expression, and consequently cell growth and proliferation. The importance of this control is supported by the fact that protein synthesis is frequently upregulated in tumor cells. The major point at which regulation occurs is the initiation stage. Initiation of translation involves the interaction of several proteins to form the eIF4F complex, the recognition of the mRNA by this complex, and the subsequent recruitment of the 40S ribosomal subunit to the mRNA. This results in the formation of the 48S complex that then scans the mRNA for the start codon, engages the methionyl-tRNA and eventually forms the mature 80S ribosome which is elongation-competent. Formation of the 48S complex is regulated by the availability of individual initiation factors and through specific protein-protein interactions. Both of these events can be regulated by post-translational modification by ubiquitin or Ubls (ubiquitin-like modifiers) such as SUMO or ISG15. We provide here a summary of translation initiation factors that are modified by ubiquitin or Ubls and, where they have been studied in detail, describe the role of these modifi...Continue Reading

References

Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N ReichJ E Darnell
May 28, 1998·The Journal of Biological Chemistry·E RomN Sonenberg
Sep 12, 1998·Molecular Cell·J M DesterroR T Hay
Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·R C DeoS K Burley
Jul 5, 2001·Molecular and Cellular Biology·K KhaleghpourN Sonenberg
Nov 28, 2001·The Journal of Biological Chemistry·Gert C ScheperChristopher G Proud
Feb 21, 2002·The Journal of Cell Biology·Jomon JosephMary Dasso
Mar 19, 2003·Differentiation; Research in Biological Diversity·Derek WalshMartin Clynes
Aug 5, 2004·The Journal of Biological Chemistry·Vikram Govind PanseEd Hurt
Nov 24, 2004·Current Opinion in Chemical Biology·Cecile M Pickart, David Fushman
Dec 14, 2004·The Journal of Biological Chemistry·J Thomas HannichMark Hochstrasser
May 19, 2005·Cell Death and Differentiation·S J MorleyM J Clemens
Jun 3, 2005·Nature·Boris PfanderStefan Jentsch
Jun 23, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Chinh T Dao, Dong-Er Zhang
Dec 15, 2005·The Journal of Biological Chemistry·Weiguo Zou, Dong-Er Zhang
May 25, 2006·The Journal of Biological Chemistry·Takayuki Murata, Kunitada Shimotohno
Oct 17, 2006·Oncogene·Y MamaneN Sonenberg
Nov 23, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jennifer M SacheckAlfred L Goldberg
Feb 10, 2007·Genes & Development·Fumihiko OkumuraDong-Er Zhang
Nov 21, 2007·Biology of the Cell·Constantina ConstantinouMichael J Clemens
Mar 21, 2008·The EMBO Journal·Julie Lagirand-CantaloubeSerge A Leibovitch
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Maria BuxadeChristopher G Proud
Aug 12, 2008·Molecular Cell·Puck KnipscheerAndrea Pichler
Dec 25, 2008·Methods in Molecular Biology·Helle D Ulrich
Feb 26, 2009·Molecular & Cellular Proteomics : MCP·Henri A BlomsterLea Sistonen
Jul 15, 2009·Molecular & Cellular Proteomics : MCP·Vittoria MataforaAngela Bachi
Jan 14, 2010·Molecular Cancer Research : MCR·Jason P LeeRobert M Gemmill
Jan 23, 2010·Nature Reviews. Molecular Cell Biology·Richard J JacksonTatyana V Pestova
Feb 16, 2010·Biochimica Et Biophysica Acta·Young Joo JeonChin Ha Chung
Mar 13, 2010·EMBO Reports·Xiang XuJing Hu

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Citations

Dec 3, 2014·Journal of Molecular Biology·Dorota KubackaJoanna Zuberek
May 11, 2016·Journal of Cell Science·Jirapas JongjitwimolFelicity Z Watts

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