Weight-bearing asymmetry and vertical activity differences in a rat model of post-traumatic knee osteoarthritis

Osteoarthritis and Cartilage
C B HamiltonB M Chesworth

Abstract

This study used a rat model of post-traumatic knee osteoarthritis (OA) created by anterior cruciate ligament transection with partial medial meniscectomy (ACLT + pMMx). In this model, mild to moderate structural changes that are typical of knee OA have been observed within 2 and 8 weeks post-surgery. We aimed to determine whether pain-related behaviours can distinguish between an ACLT + pMMx and a sham surgery group. Three-month old male Sprague-Dawley rats underwent ACLT + pMMx on their right hindlimb within two groups of n = 6 each, and sham surgery within two groups of n = 5 each. Assessments evaluated percent ipsilateral weight-bearing for static weight-bearing and 18 different variables of exploratory motor behaviour at multiple time points between 1 and 8 weeks post-surgery. Histology was performed on the right hindlimbs at 4 and 8 weeks post-surgery. Histology confirmed mild to moderate knee OA changes in the ACLT + pMMx group and the absence of knee OA changes in the sham group. Compared to the sham group, the ACLT + pMMx group had significantly lower percent ipsilateral weight-bearing from 1 through 8 weeks post-surgery. Compared to the sham group, the ACLT + pMMx group had significantly lower vertical activity (episod...Continue Reading

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Citations

Jun 4, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kristen I BartonNigel G Shrive
Aug 16, 2016·Orthopaedic Journal of Sports Medicine·Talal ZahoorZijun Zhang
Aug 23, 2019·Laboratory Animals·Brittany Y Jacobs, Kyle D Allen
Feb 2, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Germanna M BarbosaTania F Salvini
Dec 3, 2016·Current Opinion in Rheumatology·Margaret Man-Ger SunMichael A Pest
Aug 16, 2017·Experimental and Therapeutic Medicine·Xiaofeng YuHaibo Cong
Jan 19, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jessica M MotherwellChristopher L Dearth
Aug 30, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hiroko UekiHideyuki Koga

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