Weight change and cognitive performance

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
D BrubacherH B Stähelin

Abstract

To investigate whether under- or overweight and weight change is associated with cognitive performance of elderly citizens. Explorative analysis out of the Basel Study cohort. In all, 531 healthy subjects (445 men/86 women) were assessed with the Consortium to Establish a Registry for Alzheimer's Disease-Neuropsychological Assessment Battery (CERAD-NAB) in 2000 (age: 69.4+/-7.8 y) and weight measurements obtained in 1990 (body mass index (BMI): 25.2+/-3.1 kg/m(2)) and in 2000 (BMI: 25.6+/-3.4 kg/m(2)). The predictive power of the annual change in BMI with cognitive performance was investigated by a binary logistic regression analysis (backward) using sex, age, BMI 1990, BMI 2000, diastolic blood pressure, diabetes status, and optimal health status as additional predictors. In the last step, the following variables remained in the model: annual change in BMI (quadratic term; P<0.01); ApoE genotype (P<0.05); and optimal health status (P<0.01). The association between the extent of weight change and poorer cognitive performance could be either a consequence of cognitive impairment or an early symptom of neurodegenerative decline.

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Citations

Mar 28, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A K DahlN L Pedersen
Dec 22, 2012·Epidemiologic Reviews·Anna K Dahl, Linda B Hassing
Apr 8, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Anna DahlNancy L Pedersen
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Aug 7, 2012·Journal of the American Geriatrics Society·Yael D ReijmerGeert Jan Biessels
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Jan 23, 2014·Gerodontology·Frauke Müller
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Aug 4, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Emiliano AlbaneseMarcus Richards
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Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Mohammad TalaeiWoon-Puay Koh
Jun 20, 2020·Aging Clinical and Experimental Research·Yaara OrlandOdelia Elkana
Jan 17, 2021·International Journal of Environmental Research and Public Health·Darren HaywoodBarbara A Mullan
Apr 22, 2021·PloS One·Judith M KronschnablMichael Bergmann
Sep 11, 2021·Journal of Obesity & Metabolic Syndrome·Eun Mi Bae, Sang Min Park

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