Weight cycling and risk of endometrial cancer

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Victoria L StevensSusan M Gapstur

Abstract

Obesity, as measured by body mass index (BMI), is an established risk factor for endometrial cancer in postmenopausal women. Weight cycling, which consists of repeated cycles of weight loss followed by regain, occurs frequently in overweight and obese women. It is unclear whether weight cycling is associated with risk of endometrial cancer independent of BMI. This analysis included 38,148 postmenopausal women enrolled in the Cancer Prevention Study II Nutrition Cohort, of whom 559 were diagnosed with endometrial cancer between enrollment in 1992 and June 30, 2007. Number of lifetime weight cycles was determined from questions on the baseline questionnaire asking how many times 10 or more pounds were intentionally lost and later regained. Multivariable-adjusted hazard rate ratios (RR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards regression. Weight cycling was positively associated with endometrial cancer incidence (RR, 2.13; 95% CI, 1.63-2.78 for 10+ weight cycles vs. no weight cycles; P(trend) < 0.0001). However, after adjustment for BMI in 1992, this association was null (RR, 1.05; 95% CI, 0.77-1.42; P(trend) = 0.82). Weight cycling was not associated with endometrial cancer in analyses strat...Continue Reading

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Citations

Jun 5, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Heiner Boeing
Dec 12, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E O ListJ J Kopchick
Aug 9, 2015·The Lancet Oncology·UNKNOWN Collaborative Group on Epidemiological Studies on Endometrial Cancer
Sep 30, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T MehtaK Casazza
Jul 26, 2015·American Journal of Epidemiology·Victoria L StevensSusan M Gapstur
Apr 15, 2015·Endocrine-related Cancer·Tim Byers, Rebecca L Sedjo
Apr 16, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C M NagleUNKNOWN Australian National Endometrial Cancer Study Group
Aug 28, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiaochen ZhangAshley S Felix
Jan 1, 2012·Climacteric : the Journal of the International Menopause Society·Amos Pines
Jul 4, 2020·Endocrinology and Metabolism·Seung-Hwan LeeEun-Jung Rhee
Jan 11, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Laura M WeltiKristen M Beavers

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