Weight gain increases human aromatase expression in mammary gland.

Molecular and Cellular Endocrinology
Dong ChenSerdar E Bulun

Abstract

Adulthood weight gain predicts estrogen receptor-positive breast cancer. Because local estrogen excess in the breast likely contributes to cancer development, and aromatase is the key enzyme in estrogen biosynthesis, we investigated the role of local aromatase expression in weight gain-associated breast cancer risk in a humanized aromatase (Arom(hum)) mouse model containing the coding region and the 5'-regulatory region of the human aromatase gene. Compared with littermates on normal chow, female Arom(hum) mice on a high fat diet gained more weight, and had a larger mammary gland mass with elevated total human aromatase mRNA levels via promoters I.4 and II associated with increased levels of their regulators TNFα and C/EBPβ. There was no difference in total human aromatase mRNA levels in gonadal white adipose tissue. Our data suggest that diet-induced weight gain preferentially stimulates local aromatase expression in the breast, which may lead to local estrogen excess and breast cancer risk.

References

Mar 12, 1988·British Medical Journal·J S O'NeillW R Miller
May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Jun 1, 1997·American Journal of Epidemiology·A Trentham-DietzW C Willett
Aug 21, 2003·Journal of the National Cancer Institute·T J KeyUNKNOWN Endogenous Hormones Breast Cancer Collaborative Group
Apr 9, 2005·Endocrine Reviews·E R SimpsonC D Clyne
Jul 11, 2008·Cancer Letters·Dong ChenSerdar E Bulun
Apr 28, 2009·Reproductive Biology and Endocrinology : RB&E·Hong ZhaoSerdar E Bulun
Jan 15, 2010·JAMA : the Journal of the American Medical Association·Katherine M FlegalLester R Curtin
Jun 16, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ivana SestakJack Cuzick
Mar 5, 2011·Cancer Prevention Research·Kotha SubbaramaiahAndrew J Dannenberg

❮ Previous
Next ❯

Citations

Jun 13, 2012·Breast Cancer Research and Treatment·Marina PollánUNKNOWN DDM-Spain
Nov 21, 2013·International Journal of Cancer. Journal International Du Cancer·Nicolás García-ArenzanaMarina Pollán
Apr 14, 2016·Journal of Molecular Endocrinology·Hong ZhaoSerdar E Bulun
Feb 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriela Martínez-ChacónSari Mäkelä
Nov 17, 2020·Experimental and Molecular Pathology·Mete Bora TuzunerOguz Ozturk
Nov 9, 2020·Environmental Toxicology and Pharmacology·Ayse Basak Engin, Atilla Engin
Apr 30, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriela Martínez-ChacónSari Mäkelä

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved