Weight gain of HIV-exposed, uninfected children born before and after introduction of the 'Option B+' programme in Malawi

AIDS
Malango T MsukwaOlivia Keiser

Abstract

To compare birth weight and weight gain in HIV-exposed, uninfected (HEU) infants up to 24 months old, who enrolled in the Malawian national HIV care clinic (HCC) programme either before or after Option B+ (OB+) was implemented. HIV-exposed infants enrol in the HCC programme as soon as possible after birth and are followed up to at least 24 months old. This analysis includes HEU infants with recorded birth weight, date of birth, gender and at least one follow-up weight measurement from 21 health facilities in central and southern Malawi (January 2010-December 2014). Weight-for-age z scores (WAZ) were derived and compared by birth period using linear regression at birth and mixed effects models for postnatal weight gain up to 24 months old. Of 6845 HEU infants included in this study, 88.5% were born after OB+. The proportion of infants exposed in utero to combination antiretroviral therapy (ART) significantly increased after OB+ was implemented, and infants were exposed to ART for a longer time. There was no significant difference in WAZ at birth (P = 0.654) among HEU infants by birth period, but postnatal weight gain was faster among HEU infants born in the Option B+ period than infants born pre-Option B+. Birth weight was not a...Continue Reading

References

Jun 14, 2002·The New England Journal of Medicine·Ruth E TuomalaMarc Bulterys
Nov 23, 2006·AIDS·Edgardo G SzyldUNKNOWN NISDI Perinatal Study Group
Jan 9, 2007·Lancet·Sally Grantham-McGregorUNKNOWN International Child Development Steering Group
Apr 21, 2007·Tropical Medicine & International Health : TM & IH·M MakasaS Filteau
Jun 26, 2009·The American Journal of Clinical Nutrition·Stephen ArpadiLouise Kuhn
Oct 20, 2010·Tropical Medicine & International Health : TM & IH·Kartik K VenkateshGlenda E Gray
Dec 3, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kathleen M PowisRoger L Shapiro
Aug 17, 2011·Journal of the International AIDS Society·Karin van der MerweHelen Rees
Feb 14, 2012·The Pediatric Infectious Disease Journal·Taha E TahaNewton I Kumwenda
Mar 3, 2012·AIDS·George K SiberryUNKNOWN Pediatric HIV/AIDS Cohort Study (PHACS)
Oct 12, 2012·The American Journal of Clinical Nutrition·Uma Chandra Mouli NatchuWafaie W Fawzi
Oct 16, 2012·The Journal of Infectious Diseases·Jennifer Y ChenRoger L Shapiro
Nov 2, 2012·BMC Infectious Diseases·Malathi RamUNKNOWN SWEN India and BJMC-JHU Clinical Trials Study Team
Jan 1, 2014·The Pediatric Infectious Disease Journal·Jennifer Jao, Elaine J Abrams
Nov 23, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Maganizo B ChagomeranaKimberly A Powers

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Citations

Mar 21, 2019·Tropical Medicine & International Health : TM & IH·Malango T MsukwaJanne Estill
Oct 21, 2019·Current HIV/AIDS Reports·Allison Ross EckardNancy L Hagood

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