Weight gain with clozapine: 8-year cohort naturalistic study among hospitalized Chinese schizophrenia patients

Schizophrenia Research
Ya Mei BaiChao-Cheng Lin

Abstract

Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous outpatient studies may be due to many confounding factors, such as variations in drug adherence, diet content, activity level and environmental factors. The objective of this study was to investigate long-term weight changes in hospitalized Chinese schizophrenic patients treated with clozapine. Patients were admitted at the largest mental hospital in Taiwan and had routine monthly body weight monitoring during the study period. Retrospective chart reviews were conducted to obtain demographic data, age at which clozapine treatment was initiated, and weight changes after the initiation of clozapine treatment. The study sample consisted of 349 hospitalized schizophrenic patients, including 204 males (58.8%), with an average age at clozapine initiation of 38.6+/-9.3 and an average clozapine dosage of 318+/-9.3 mg/day. Body weight increased over time, and reached a plateau at month 42. Younger age at clozapine initiation (P=0.0038) and lower baseline body mass index (BBMI) (P<0.0001) were asso...Continue Reading

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Citations

Feb 14, 2013·Current Psychiatry Reports·Ursula WernekeThomas A B Sanders
Jul 17, 2013·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Yu-Tsung LiuChing-Yen Chen
Aug 9, 2020·Issues in Mental Health Nursing·Sujatha Sanjeevi, Angela Cocoman
Jul 28, 2016·Clinical Schizophrenia & Related Psychoses·Leslie CitromeStephen R Saklad
Feb 13, 2016·Journal of Clinical Psychopharmacology·Sue Lynn LauDorgival Caetano
Dec 3, 2011·CNS Drugs·James L RoerigJames E Mitchell

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