PMID: 15235324Jul 6, 2004Paper

Weight loss and exercise: implications for muscle lipid metabolism and insulin action

Medicine and Science in Sports and Exercise
Jason R BerggrenJoseph A Houmard

Abstract

Implications for Muscle Lipid Metabolism and An accumulation of intramuscular lipid has been reported with obesity and linked with insulin resistance. The purpose of this paper is to discuss: 1) mechanisms that may be responsible for intramuscular lipid accumulation with obesity, and 2) the effects of common interventions (weight loss or exercise) for obesity on skeletal muscle lipid metabolism and intramuscular lipid content. Data suggest that the skeletal muscle of morbidly obese humans is characterized by the preferential partitioning of lipid toward storage rather than oxidation. This phenotype may, in part, contribute to increased lipid deposition in both muscle and adipose tissue, and promote the development of morbid obesity and insulin resistance. Weight loss intervention decreases intramuscular lipid content, which may contribute to improved insulin action. On the other hand, exercise training improves insulin action and increases fatty acid oxidation in the skeletal muscle of obese/morbidly obese individuals. In summary, the accumulation of intramuscular lipid appears to be detrimental in terms of inducing insulin resistance; however, the accumulation of lipid can be reversed with weight loss. The mechanism(s) by whic...Continue Reading

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Citations

Jul 10, 2014·Journal of Aging Research·Lucas Whitcher, Charilaos Papadopoulos
Feb 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph A Houmard
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·David Wright, Lindsey Sutherland
Mar 27, 2012·European Journal of Applied Physiology·Billy SperlichHans-Christer Holmberg
Apr 13, 2012·Journal of Obesity·Catherine LingSheila Smith
Jun 1, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Edward Shang, Till Hasenberg
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Jun 24, 2010·Orvosi hetilap·Péter Apor, Attila Rádi
Apr 28, 2005·Diabetes·Dustin S HittelJoseph A Houmard
Apr 10, 2007·Exercise and Sport Sciences Reviews·Jason R BerggrenJoseph A Houmard
May 4, 2006·American Journal of Physiology. Endocrinology and Metabolism·Simon Schenk, Jeffrey F Horowitz
Jul 31, 2010·Research in Nursing & Health·Sara Fleet Michaliszyn, Melissa Spezia Faulkner
May 2, 2017·Journal of Sports Medicine·J SlaghtD R Bouchard
Dec 6, 2018·Frontiers in Psychology·Martine Van PuyveldeNathalie Pattyn
May 14, 2020·International Journal of Environmental Research and Public Health·Lukáš JakubecDorota Groffik
Oct 8, 2020·International Journal of Environmental Research and Public Health·Francisco Jesús Llorente-CantareroRosaura Leis
Feb 20, 2018·Jornal de pediatria·Sarah A Vieira-RibeiroSylvia C C Franceschini
May 1, 2021·International Journal of Environmental Research and Public Health·Massimo De NardiRoberto Codella
May 11, 2012·Nutrition & Metabolism·Audrey D EavesJoseph A Houmard
Jun 26, 2007·Diabetes Care·Yiling J ChengHenry S Kahn

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