Weight-loss diets and 2-y changes in circulating amino acids in 2 randomized intervention trials

The American Journal of Clinical Nutrition
Yan ZhengLu Qi

Abstract

Circulating amino acids, such as branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs), have been associated with diabetes risk; however, little is known about how a long-term dietary intervention for weight loss affects circulating amino acids. We examined the effects of weight-loss diets on long-term changes in plasma amino acids and the associations of these changes with weight loss and the improvement of insulin resistance. We repeatedly measured plasma amino acid profiles over 2 y in overweight or obese participants from 2 randomized, dietary intervention, weight-loss trials [774 subjects from the POUNDS LOST (Preventing Overweight Using Novel Dietary Strategies Trial) and 318 subjects from the DIRECT (Dietary Intervention Randomized Controlled Trial)]. Intervention diets consistently lowered most of the amino acid concentrations, including BCAAs and AAAs, in both trials. In the POUNDS LOST, average-protein diets (15% of daily energy) showed stronger effects than did high-protein diets (25% of daily energy) on reducing concentrations of the diabetes-associated BCAA valine at 6 mo independent of the weight change. In both trials, weight loss was directly related to the concurrent reduction of the BCAAs leucine ...Continue Reading

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Citations

Apr 8, 2017·International Journal of Molecular Sciences·Yoriko Heianza, Lu Qi
Jul 4, 2017·Pediatric Pulmonology·Antonia BarcelóMónica de la Peña
Jul 12, 2018·Current Opinion in Cardiology·Deirdre K TobiasPatrick R Lawler
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Jun 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Xiang LiLu Qi
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May 22, 2019·International Journal of Molecular Sciences·Borros ArnethMohamed Shams
Jul 31, 2019·International Journal of Molecular Sciences·Xiang Li, Lu Qi
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Jul 16, 2021·Translational Medicine of Aging·Reji Babygirija, Dudley W Lamming
Jul 16, 2021·Circulation. Genomic and Precision Medicine·Rikuta HamayaDeirdre K Tobias

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