Abstract
The ketogenic diet (KD) is being increasingly promoted as a strategy to fight obesity. Although the KD is effective for weight loss and weight control, comprehensive determination of its relationship with biochemical, physiological and psychological changes is still largely unexplored. We hypothesized that a 12-week KD (12KD) would significantly affect body weight, physical performance, cognitive function, eating behaviors, the metabolic and hormonal profile in obese adults, although differently in men and women. In an uncontrolled intervention, 35 sedentary obese adults (13 men, 25 women), aged 37 ± 7 years with a BMI 36.1 ± 5.6 kg/m2 underwent a 12KD between March 2017 and June 2017 at the University of Primorska. The 12KD resulted in decreased appetite, significant weight loss of participants (-18 ± 9 kg men vs. -11 ± 3 kg women; P < .001), decreased emotional and external eating (P < .001 for both), increased body image satisfaction (P < .001) and improved physical performance (P < .001). Biochemically, a significant drop in glucose (P = .026), and a significant increase in LDL-cholesterol (P = .031), CRP (P = .007), and BDNF (P = .035) were observed in the first 2 weeks; then, all listed parameters returned to baseline. On...Continue Reading
Citations
Nov 16, 2019·Nutrients·Heather Seid, Michael Rosenbaum
Sep 10, 2019·Journal of Alzheimer's Disease : JAD·Aurélie LedreuxAbdul Kadir H Mohammed
Dec 18, 2019·Nutrition Reviews·Agnes Ayton, Ali Ibrahim
Jul 4, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Rachel H Freire, Jacqueline I Alvarez-Leite
Jan 24, 2020·Brain Plasticity·Patrick J Smith
Jun 10, 2020·Reviews in Endocrine & Metabolic Disorders·Borja Bandera-MerchanFrancisco J Tinahones
Jul 28, 2019·The American Journal of Clinical Nutrition·Matthew Sherrier, Hongshuai Li
Apr 14, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·J K C RibeiroV M Ceccatto
Sep 3, 2020·Obesity·Alessandra LodiAntonio Paoli
Jul 1, 2020·Advances in Nutrition·Maria G GrammatikopoulouDimitrios P Bogdanos
May 7, 2020·International Journal of Molecular Sciences·Vincenzo MondaGiovanni Messina
Jun 17, 2020·Journal of the Endocrine Society·Christopher Spoke, Samar Malaeb
Oct 10, 2020·Curēus·Safia ShaikhBenjamin Harris
Jan 23, 2021·Nature Medicine·Kevin D HallStephanie T Chung
Feb 4, 2021·Nutrients·Antonio PaoliTatiana Moro
Mar 16, 2021·Frontiers in Nutrition·Ingrid Elisia, Gerald Krystal
Apr 28, 2021·Physiology·Simone C da Silva RosaGary Sweeney
Apr 23, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Jessica Roekenes, Catia Martins
May 16, 2020·Cancer Cell·Mylène Tajan, Karen H Vousden
Jun 1, 2021·Current Developments in Nutrition·Michael J WengerJere D Haas
May 18, 2021·World Journal of Diabetes·Prashant NasaAanchal Singh
Jun 3, 2021·Nutrients·Kathryn Dowis, Simran Banga
Jul 3, 2021·Nutrients·Ladislav PilařIvana Tichá
Jul 29, 2021·Current Obesity Reports·Sylvain IcetaAndréanne Michaud
Sep 18, 2021·Endocrine·Mariangela RondanelliClara Gasparri
Nov 11, 2021·Advances in Nutrition·Lauren PickelHoon-Ki Sung
Jan 20, 2022·Worldviews on Evidence-based Nursing·Audra HannersMarjorie M Kelley