Weight loss in patients with diabetes treated with a metformin-sulfonylurea combination in comparison with twice-daily mixed insulin.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
David S H Bell, M S Mayo

Abstract

To investigate whether patients previously treated with insulin or sulfonylureas alone can be transferred to a combination of sulfonylureas and metformin therapy and realize a prolonged weight loss. We conducted a retrospective review of medical records to identify three groups of patients with type 2 diabetes: group 1, those requiring insulin who had remained on a daily regimen of two injections of mixed insulin; group 2, patients whose regimen had been changed from sulfonylureas alone to a combination of a sulfonylurea and metformin; and group 3, patients whose regimen had been converted from twice-daily mixed insulin alone to a sulfonylurea-metformin combination. Results relative to loss of weight in these three groups were analyzed. For a 12-month period, no significant weight loss was noted in group 1, and group 2 showed a small nonsignificant weight loss in 6 months. Only group 3 had a significant weight loss at 3, 6, 9, and 12 months, maximizing at a mean weight loss of 22 lb (10 kg) at 12 months. In addition, in those patients in whom data were available, a significant weight loss was found at 18 and 21 months. At 21 months, however, weight began to increase. Percentage weight loss followed a pattern similar to that see...Continue Reading

References

Jun 1, 1992·Diabetes Care·C J Bailey
Jul 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·S Josephkutty, J M Potter
Sep 1, 1985·Metabolism: Clinical and Experimental·J RodinR A DeFronzo
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Mar 1, 1997·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell, M S Mayo
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell, M S Mayo

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Citations

Mar 10, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell, F Ovalle
Jul 13, 2002·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·James H HaysK M M Shakir
Aug 14, 2002·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·David S H Bell, Fernando Ovalle
Aug 15, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·David S H Bell
Mar 10, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·F Ziel, R Nakahiro
Aug 18, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·David S H Bell
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell, F Ovalle

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