PMID: 8453258Jan 1, 1993Paper

Weight loss in patients with hematological neoplasias is associated with immune system stimulation

The Clinical Investigator
H DenzD Fuchs

Abstract

Weight loss is the main symptom of so-called tumor cachexia. The pathogenetic mechanisms underlying cachexia are poorly understood; however, it appears that enhanced formation of cytokines such as interferon-gamma and tumor necrosis factor-alpha are involved. In 94 patients suffering from hematological neoplasias we compared body weight changes with serum neopterin, tryptophan, and kynurenine. Biochemical changes, the formation of neopterin, the degradation of tryptophan are closely related to interferon-gamma activity. The majority of our patients had increased neopterin and decreased tryptophan concentrations. Weight loss was seen particularly in patients with higher neopterin and lower tryptophan values. An association between higher neopterin levels and greater weight loss was apparent at study entry and during the follow-up of patients. Our data support the concept that weight loss is closely linked to endogenous interferon-gamma activity.

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Citations

Mar 16, 2007·Journal of Cancer Research and Clinical Oncology·Katharina SchroecksnadelDietmar Fuchs
Oct 1, 1996·Cancer Letters·Z Z AltindagD Fuchs
Dec 14, 2002·Life Sciences·Katharina SchröcksnadelDietmar Fuchs
Apr 27, 2000·Immunology Today·B WidnerD Fuchs
Jan 1, 1997·Cancer Letters·S MurrayM R Albertini
Oct 29, 2002·Brain, Behavior, and Immunity·Bernhard WidnerDietmar Fuchs
Sep 28, 2010·Amino Acids·Nathalie Le Floc'hElodie Merlot
Jun 9, 2009·Cancer Letters·Robert SucherGerald Brandacher
Jun 3, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yuzo SuzukiKingo Chida
Aug 26, 2009·European Journal of Cancer Care·A B EnginS Yardim-Akaydin
May 18, 2005·Cancer Letters·Katharina SchroecksnadelDietmar Fuchs
Sep 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katharina SchröcksnadelDietmar Fuchs
Feb 17, 2015·Expert Opinion on Therapeutic Targets·Johanna M GostnerDietmar Fuchs
Feb 14, 2004·European Journal of Haematology·Guenter WeissDietmar Fuchs
Jul 24, 2018·CNS Spectrums·Gabriella PravettoniAlberto Priori
Jun 18, 2018·Respiration; International Review of Thoracic Diseases·Anna Smukowska-GoryniaTatiana Mularek-Kubzdela
Nov 16, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Katharina KurzDietmar Fuchs
Jun 19, 2009·Expert Opinion on Therapeutic Targets·P H Tan, A K Bharath
Jan 1, 2009·International Journal of Tryptophan Research : IJTR·Yiquan Chen, Gilles J Guillemin
Oct 13, 2021·Journal of Cachexia, Sarcopenia and Muscle·Silvia CataneseUlrich T Hacker

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