Weight loss increases all-cause mortality in overweight or obese patients with diabetes: A meta-analysis

Medicine
Yiqi ChenHuijuan Yuan

Abstract

Overweight and obese patients with diabetes are advised to lose weight to improve their health; however, recent studies have demonstrated that weight loss may be associated with worse long-term survival in patients with diabetes. This meta-analysis aimed to examine the relationships between weight loss and all-cause mortality in overweight or obese individuals with diabetes. We searched the PubMed and EMBASE databases from inception to February 2017. We included prospective studies that reported sufficient information to extract mortality-specific relative risks (RRs) with corresponding 95% confidence intervals (CIs). RRs with 95% CIs were pooled using a random-effects model. A subgroup analysis was also performed to explore sources of heterogeneity. Of the 1652 studies identified, 8 met the inclusion criteria. A total of 18,887 patients were included in this analysis. We found that compared with a stable weight, weight loss was associated with an increased risk of all-cause mortality (RR, 1.15; 95% CI, 1.04 to 1.28) and cardiovascular disease (CVD) mortality (RR, 1.15; 95% CI, 1.02 to 1.29) in overweight or obese adults with diabetes, whereas intentional weight loss was not associated with changes in all-cause mortality (RR, 0...Continue Reading

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Citations

Oct 8, 2019·The Journal of Clinical Endocrinology and Metabolism·Alexandra K LeeElizabeth Selvin
Jul 25, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·George A KelleyBrian L Stauffer
Sep 22, 2020·Eating and Weight Disorders : EWD·Giovanni GravinaGrazia Nebbiai
Mar 14, 2020·Current Cardiology Reports·Alok Kumar DwivediSireesha Y Reddy
Jul 3, 2021·International Journal of Molecular Sciences·Russell T TurnerUrszula T Iwaniec

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