Weight Loss Medications in Young Adults after Bariatric Surgery for Weight Regain or Inadequate Weight Loss: A Multi-Center Study

Children
Alexander T TothFatima Cody Stanford

Abstract

This paper presents a retrospective cohort study of weight loss medications in young adults aged 21 to 30 following Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) between November 2000 and June 2014. Data were collected from patients who used topiramate, phentermine, and/or metformin postoperatively. Percentage of patients achieving ≥5%, ≥10%, or ≥15% weight loss on medications was determined and percent weight change on each medication was compared to percent weight change of the rest of the cohort. Our results showed that 54.1% of study patients lost ≥5% of their postsurgical weight; 34.3% and 22.9% lost ≥10% and ≥15%, respectively. RYGB had higher median percent weight loss (-8.1%) than SG (-3.3%) (p = 0.0515). No difference was found in median percent weight loss with medications started at weight plateau (-6.0%) versus after weight regain (-5.4%) (p = 0.5304). Patients taking medications at weight loss plateau lost 41.2% of total body weight from before surgery versus 27.1% after weight regain (p = 0.076). Median percent weight change on metformin was -2.9% compared to the rest of the cohort at -7.7% (p = 0.0241). No difference from the rest of the cohort was found for phentermine (p = 0.2018) or topiramate (p...Continue Reading

References

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Citations

Dec 24, 2018·Expert Opinion on Pharmacotherapy·Javier Gargallo-VaamondeJavier Salvador
Apr 9, 2020·Frontiers in Endocrinology·Fatima Cody StanfordVibha Singhal
Apr 16, 2020·Expert Opinion on Pharmacotherapy·Kishore M Gadde, Katelyn D Atkins
Nov 16, 2019·Current Diabetes Reports·Hope T JacksonFatima Cody Stanford
Jan 10, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Colston EdgertonAli Tavakkoli
Jan 26, 2021·Current Obesity Reports·Ilana P RedmondLouis J Aronne

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Methods Mentioned

BETA
gastric bypass
pharmacotherapy

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