PMID: 4887385Apr 5, 1969Paper

Weight-reducing effect of diguanides in obese non-diabetic women

British Medical Journal
J F MunroL J Duncan

Abstract

A double-blind trial was carried out to assess the weight-reducing effect of the diguanides in 90 women with refractory obesity and normal oral glucose tolerance. The daily dosage of phenformin and metformin was increased at weekly intervals up to 300 mg. and 3 g. respectively, and patients were maintained at this dose or on the maximum they could tolerate without anorexia or other gastrointestinal side-effects. Seventy-seven completed the 16-week period of study. There was a statistically significant difference between the mean weight change of the control and the treated groups, but no difference between those treated by phenformin or metformin. The weight-losing influence of the diguanides appeared to be no longer significant after the twelfth week of treatment.

References

Mar 26, 1968·Annals of the New York Academy of Sciences·M S Roginsky, J Sandler
Oct 28, 1967·British Medical Journal·D W Proctor, J M Stowers
Mar 26, 1968·Annals of the New York Academy of Sciences·G L Searle, R R Cavalieri
Sep 10, 1966·British Medical Journal·J F MunroL J Duncan
Apr 6, 1963·JAMA : the Journal of the American Medical Association·R E TRANQUADAH E MARTIN

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Citations

Dec 1, 1971·Physiology & Behavior·E BrieseL Hernandez
Aug 23, 2006·Cardiology in Review·Kerri L PalamaraWilliam H Frishman
Feb 19, 2011·Journal of Obesity·Mariela Glandt, Itamar Raz
Apr 4, 2002·Drugs·José-Antonio Fernández-LópezMarià Alemany
Dec 9, 2014·Diabetes, Obesity & Metabolism·M A AdeyemoJ A Yanovski
Aug 10, 2001·Pediatric Clinics of North America·J A Yanovski
Nov 1, 1972·Clinics in Endocrinology and Metabolism·J M Malins
Mar 1, 2006·American Heart Journal·Tracy DeWaldGeorge Blackburn
May 15, 2008·The Annals of Pharmacotherapy·Alicia R DesiletsKaelen C Dunican
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D S Bell, M S Mayo
Feb 7, 1970·The Medical Journal of Australia·P Lim, O T Khoo

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