Weight restoration therapy rapidly reverses cortical thinning in anorexia nervosa: A longitudinal study

NeuroImage
Fabio BernardoniStefan Ehrlich

Abstract

Structural magnetic resonance imaging studies have documented reduced gray matter in acutely ill patients with anorexia nervosa to be at least partially reversible following weight restoration. However, few longitudinal studies exist and the underlying mechanisms of these structural changes are elusive. In particular, the relative speed and completeness of brain structure normalization during realimentation remain unknown. Here we report from a structural neuroimaging study including a sample of adolescent/young adult female patients with acute anorexia nervosa (n=47), long-term recovered patients (n=34), and healthy controls (n=75). The majority of acutely ill patients were scanned longitudinally (n=35): at the beginning of standardized weight restoration therapy and again after partial weight normalization (>10% body mass index increase). High-resolution structural images were processed and analyzed with the longitudinal stream of FreeSurfer software to test for changes in cortical thickness and volumes of select subcortical regions of interest. We found globally reduced cortical thickness in acutely ill patients to increase rapidly (0.06 mm/month) during brief weight restoration therapy (≈3 months). This significant increase...Continue Reading

References

Oct 1, 1977·Journal of Computer Assisted Tomography·D R Enzmann, B Lane
May 1, 1988·Psychological Medicine·R J DolanA Wakeling
Aug 1, 1997·Archives of Pediatrics & Adolescent Medicine·D K KatzmanD J Mikulis
Aug 3, 1999·Pediatrics·L Benítez-BribiescaA Mansilla-Olivares
Nov 7, 1999·The International Journal of Eating Disorders·K LowingerS W Touyz
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Mar 14, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·M Fichter, N Quadflieg
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Jun 7, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stewart Shipp
Sep 6, 2005·Biological Psychiatry·Angela WagnerWalter H Kaye
Feb 28, 2006·European Child & Adolescent Psychiatry·Stefan EhrlichErnst Pfeiffer
Aug 24, 2006·Journal of Affective Disorders·N T GodartM F Flament
Dec 7, 2006·The British Journal of Clinical Psychology·Ulrike Schmidt, Janet Treasure
Dec 7, 2007·The American Journal of Psychiatry·Mark MühlauSabine Nunnemann
Mar 5, 2008·Journal of Neural Transmission·Stefan EhrlichUlrike Lehmkuhl
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip ShawSteve P Wise
May 20, 2008·Journal of Psychiatric Research·Josefina Castro-FornielesCarme Junqué
Nov 19, 2008·Child and Adolescent Psychiatric Clinics of North America·Hans-Christoph Steinhausen
Mar 20, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stefan EhrlichJohannes Hebebrand
Sep 5, 2009·Behavioural Brain Research·Boris SuchanSilja Vocks
Jul 20, 2010·NeuroImage·Martin ReuterBruce Fischl
Jan 25, 2011·Journal of Neural Transmission·M FöckerJ Hebebrand
Mar 8, 2011·NeuroImage·Martin Reuter, Bruce Fischl
Jun 11, 2011·The International Journal of Eating Disorders·Christina A RobertoB Timothy Walsh
Nov 5, 2011·European Eating Disorders Review : the Journal of the Eating Disorders Association·Frederique Van den EyndeUlrike Schmidt
Mar 6, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sylvie Caspar-BauguilPatrick Ritz
Mar 20, 2012·Nature Neuroscience·Robert J ZatorreHeidi Johansen-Berg
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
May 29, 2012·Neuron·Olaf BergmannJonas Frisén
Nov 6, 2012·NeuroImage·Jorge L Bernal-RusielUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 22, 2013·Trends in Neurosciences·Walter H KayeAmanda Bischoff-Grethe

❮ Previous
Next ❯

Citations

Jul 13, 2016·Human Brain Mapping·Gerit PfuhlStefan Ehrlich
Jul 15, 2016·The International Journal of Eating Disorders·Sahib S KhalsaJamie D Feusner
Mar 15, 2018·Praxis·Gabriella Milos, Eleonora Brunner
Aug 29, 2018·Psychological Medicine·Nina von SchwanenflugStefan Ehrlich
Sep 14, 2018·The International Journal of Eating Disorders·Kathrin NickelSimon Maier
Jan 10, 2019·Psychological Medicine·Daniel GeislerStefan Ehrlich
May 10, 2019·PloS One·Enrico CollantoniAngela Favaro
Jul 16, 2019·Current Opinion in Psychiatry·Joanna E SteinglassKarin Foerde
Dec 18, 2019·European Eating Disorders Review : the Journal of the Eating Disorders Association·Emilia KotPalmiero Monteleone
Aug 10, 2020·Journal of Neuroscience Research·Vincenzo AlfanoMariachiara Longarzo
Nov 18, 2016·BMC Psychiatry·Tone Seim FuglsetØyvind Rø
Jul 16, 2017·Scientific Reports·Franziska RitschelStefan Ehrlich
Oct 3, 2017·European Eating Disorders Review : the Journal of the Eating Disorders Association·Katherine SchaumbergCynthia M Bulik
Nov 10, 2017·The International Journal of Eating Disorders·Lasse BangTor Endestad
Dec 8, 2017·Journal of Eating Disorders·Lasse BangAndreas Joos
May 10, 2019·F1000Research·Guido K W FrankMarisa C DeGuzman
Feb 7, 2018·The International Journal of Eating Disorders·Guido K W FrankElizabeth A Lawson
Jun 7, 2019·European Eating Disorders Review : the Journal of the Eating Disorders Association·Kathrin NickelSimon Maier
Jul 12, 2020·Scientific Reports·Derek HowardLeon French
Jun 24, 2017·European Radiology·José BotoMaria Isabel Vargas
Feb 8, 2018·The International Journal of Eating Disorders·Luca LavagninoGuido K W Frank
Jun 7, 2019·European Eating Disorders Review : the Journal of the Eating Disorders Association·Jenni LeppanenKate Tchanturia
Mar 9, 2019·European Archives of Psychiatry and Clinical Neuroscience·Josefina Castro-FornielesNúria Bargalló
Mar 17, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·O CurzioA Retico
Mar 25, 2020·Journal of Clinical Medicine·Enrico CollantoniAngela Favaro
Aug 11, 2018·Current Psychiatry Reports·Anna M Bardone-ConeHunna J Watson
Aug 3, 2019·Translational Psychiatry·Ida A K NilssonMikael Landén
May 6, 2020·Translational Psychiatry·Lisa-Katrin KaufmannGabriella Milos
Oct 31, 2020·European Eating Disorders Review : the Journal of the Eating Disorders Association·Lasse BangØyvind Rø
Nov 12, 2020·Expert Review of Clinical Pharmacology·Johanna KeelerJanet Treasure
Jan 22, 2021·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kentaro UmedaShuji Iritani
Feb 6, 2021·Translational Psychiatry·Feliberto de la CruzKarl-Jürgen Bär
Nov 13, 2020·Translational Psychiatry·Maria SeidelStefan Ehrlich
Nov 14, 2020·European Eating Disorders Review : the Journal of the Eating Disorders Association·Enrico CollantoniAngela Favaro
Feb 5, 2021·Frontiers in Human Neuroscience·Olga Tymofiyeva, Robert Gaschler
Dec 29, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Stefan Ehrlich, Friederike I Tam
Nov 19, 2017·Psychiatry Research. Neuroimaging·Margaret L WestwaterJames C Thompson
Mar 24, 2021·Eating and Weight Disorders : EWD·Enrico CollantoniAngela Favaro

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.