Weight stability in Parkinson's disease

Nutritional Neuroscience
Susanne LindskovAlbert Westergren

Abstract

Parkinson's disease (PD) has traditionally been associated with weight loss. However, recent studies have not found any evidence of underweight in PD. Nevertheless, few studies have addressed nutritional status changes over time in relation to other clinical PD features. Here, we explore changes in nutritional status and motor and non-motor PD features (including dopaminergic drug therapy) in PD patients after 1 year. Motor and non-motor PD features, dopaminergic drug therapy, under-nutrition and malnutrition risk, and anthropometric measures (BMI, handgrip strength, triceps skin-fold, mid-arm circumference, and mid-upper arm muscle circumference) were assessed at baseline and 1 year later among 65 people with PD. Disability, PD motor symptoms, dysautonomia, and dopaminergic drug therapy increased. Underweight was uncommon both at baseline (n = 3) and follow-up (n = 2); malnutrition risk was common but stable (88 and 92%), whereas triceps skin-fold increased (P = 0.030); mid-upper arm muscle circumference decreased (P = 0.002); and the proportion of people with low handgrip strength (P = 0.012) increased. Correlations between nutritional variables and motor and non-motor PD features were absent to modest. Multiple linear regres...Continue Reading

References

Jun 1, 1990·Aging : Clinical and Experimental Research·I Mattiasson-NiloG Grimby
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
May 1, 1981·Social Science & Medicine. Part A, Medical Sociology·S M HuntE Papp
Jan 26, 2000·Journal of the American Dietetic Association·M F KuczmarskiM Najjar
Dec 7, 2002·Clinical Neuropharmacology·Johan MarinusJacobus J van Hilten
Apr 3, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Gun-Marie HarizA Tommy Bergenheim
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Martine VisserJacobus J Van Hilten
Nov 7, 2006·Journal of Pain and Symptom Management·Peter HagellDavid Cella
Jan 1, 2008·The Journal of Nutrition, Health & Aging·A WestergrenK Ulander
Apr 9, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Mauro ZamboniVincenzo Di Francesco
Apr 30, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Maria G Cersosimo, Eduardo E Benarroch
May 27, 2008·Practical Neurology·P E Smith
Jun 13, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michael Maia SchlüsselGilberto Kac
Sep 11, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Stanley Fahn
Nov 17, 2009·Lancet Neurology·Walter MaetzlerDaniela Berg
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Nov 3, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kristina NormanMatthias Pirlich
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Mar 25, 2011·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Roy FreemanJ Gert van Dijk
Sep 16, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R F CogliandroV Stanghellini
Nov 22, 2011·Parkinsonism & Related Disorders·Marjolein A van der MarckMarten Munneke
Dec 6, 2011·Neurorehabilitation and Neural Repair·Jennifer Stevens-LapsleyMargaret Schenkman
Nov 24, 2012·Arquivos de neuro-psiquiatria·Hugo Morales-BriceñoTeresa Corona
Apr 26, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Anna FloodTherese A O'Sullivan
Jan 16, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Magdalena VikdahlLena Håglin

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Citations

Jul 14, 2017·Frontiers in Aging Neuroscience·Luxi WangTao Wang
Oct 14, 2017·Scandinavian Journal of Medicine & Science in Sports·G Grimby, K Frändin
Jul 26, 2017·BioMed Research International·Jacek WilczyńskiDawid Mucha
Apr 10, 2018·Frontiers in Aging Neuroscience·Tino Prell, Caroline Perner
Feb 23, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Shengfang SongHonglei Chen
Aug 19, 2021·Movement Disorders Clinical Practice·Jessica RivadeneyraEsther Cubo

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