PMID: 11926663Apr 3, 2002Paper

Weight variability of pharmacist-dispensed split tablets

Journal of the American Pharmaceutical Association : APhA
Jack M RosenbergFotios Plakogiannis

Abstract

To determine the level of weight uniformity of fragments from tablets split into halves and dispensed by pharmacists. Pre-post comparison. Laboratory analysis of split tablets returned unused from four long-term care facilities. Twenty-two dispensed prescriptions containing 560 split tablet halves were collected, and fragment weights (FWs) were determined. Theoretical weights (TWs) of split tablets of the same medications were determined mathematically. Comparison of the mean FW with the mean TW of each dispensed prescription and determination of whether fragments met United States Pharmacopeia 24 (USP) criteria for weight variation of whole tablets. A significant difference (P < .05) between mean TW and mean FW was found in 2 (9.1%) of the 22 dispensed prescriptions. Overall, 30 (5.4%) of 560 fragments, contained in 10 (45.5%) of the 22 dispensed prescriptions, had weights that deviated by more than 15% from the mean FW. Of the 560 fragments, 32 (5.7%), contained in 10 (45.5%) of 22 dispensed prescriptions, had weights that deviated by more than 15% from mean TW. A total of 15 (68.2%) of the 22 dispensed prescriptions had standard deviations (SDs) that were more than 6% of the mean FW. None of the TWs displayed an SD greater t...Continue Reading

Citations

May 4, 2013·Indian Journal of Pediatrics·R BalasubramaniamShalini Sri Ranganathan
May 18, 2012·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Maisha Kelly FreemanMaryam Iranikhah
Feb 6, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nienke RodenhuisDirk M Barends
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