Weighted cue integration in the rodent head direction system

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Rebecca KnightKathryn J Jeffery

Abstract

How the brain combines information from different sensory modalities and of differing reliability is an important and still-unanswered question. Using the head direction (HD) system as a model, we explored the resolution of conflicts between landmarks and background cues. Sensory cue integration models predict averaging of the two cues, whereas attractor models predict capture of the signal by the dominant cue. We found that a visual landmark mostly captured the HD signal at low conflicts: however, there was an increasing propensity for the cells to integrate the cues thereafter. A large conflict presented to naive rats resulted in greater visual cue capture (less integration) than in experienced rats, revealing an effect of experience. We propose that weighted cue integration in HD cells arises from dynamic plasticity of the feed-forward inputs to the network, causing within-trial spatial redistribution of the visual inputs onto the ring. This suggests that an attractor network can implement decision processes about cue reliability using simple architecture and learning rules, thus providing a potential neural substrate for weighted cue integration.

References

Jun 1, 1997·Experimental Brain Research·P A DudchenkoJ S Taube
Nov 22, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Rotenberg, R U Muller
Sep 1, 2000·Experimental Brain Research·M B ZugaroS I Wiener
Aug 2, 2003·Journal of Neurophysiology·Robert W StackmanJeffrey S Taube
Jul 6, 2004·The European Journal of Neuroscience·Michaël B ZugaroSidney I Wiener
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·D YoganarasimhaJames J Knierim
Mar 8, 2007·Annual Review of Neuroscience·Jeffrey S Taube
Feb 10, 2010·Behavioral Neuroscience·Matthijs A A van der MeerPaul A Dudchenko
Sep 25, 2010·Hippocampus·Lorenzo PogliaIrina Nikonenko
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca KnightKathryn Jeffery
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hector J I PageSimon M Stringer

❮ Previous
Next ❯

Citations

Mar 26, 2016·Frontiers in Neural Circuits·Andrey L Shilnikov, Andrew Porter Maurer
Nov 27, 2015·The Journal of Physiology·Talfan EvansNeil Burgess
Dec 20, 2016·Nature Neuroscience·Pierre-Yves JacobKate Jeffery
Jul 11, 2016·NeuroImage·Iole IndovinaFrancesco Lacquaniti
Mar 15, 2018·Journal of Neurophysiology·Shahaf Weiss, Dori Derdikman
Jan 1, 2018·Network : Computation in Neural Systems·Hector J I PageSimon M Stringer
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tom HartleyJohn O'Keefe
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hector J I PageSimon M Stringer
May 3, 2018·Journal of Neurophysiology·Stefano ColettaAndrea Burgalossi
Mar 27, 2020·Journal of Neurophysiology·Jeffrey S Taube, Michael E Shinder
May 11, 2018·Nature·Andrea BaninoDharshan Kumaran
Sep 25, 2018·Brain and Neuroscience Advances·Yave Roberto LozanoKate Jeffery
Aug 1, 2018·Frontiers in Cellular Neuroscience·Hector J I Page, Kate J Jeffery
Feb 8, 2019·The Journal of Experimental Biology·Nora S Newcombe
Aug 2, 2016·The Journal of Physiology·Kate J JefferySimon M Stringer
Sep 18, 2018·Brain and Neuroscience Advances·Anna S MitchellAndrew J D Nelson
Feb 16, 2019·The Behavioral and Brain Sciences·Mintao Zhao, William H Warren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.