Weighted Stochastic Block Models of the Human Connectome across the Life Span

Scientific Reports
Joshua FaskowitzOlaf Sporns

Abstract

The human brain can be described as a complex network of anatomical connections between distinct areas, referred to as the human connectome. Fundamental characteristics of connectome organization can be revealed using the tools of network science and graph theory. Of particular interest is the network's community structure, commonly identified by modularity maximization, where communities are conceptualized as densely intra-connected and sparsely inter-connected. Here we adopt a generative modeling approach called weighted stochastic block models (WSBM) that can describe a wider range of community structure topologies by explicitly considering patterned interactions between communities. We apply this method to the study of changes in the human connectome that occur across the life span (between 6-85 years old). We find that WSBM communities exhibit greater hemispheric symmetry and are spatially less compact than those derived from modularity maximization. We identify several network blocks that exhibit significant linear and non-linear changes across age, with the most significant changes involving subregions of prefrontal cortex. Overall, we show that the WSBM generative modeling approach can be an effective tool for describin...Continue Reading

References

Mar 7, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K E StephanR Kötter
Jul 24, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Elizabeth R SowellArthur W Toga
Jan 6, 2006·Annals of the New York Academy of Sciences·D H SalatA M Dale
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Jul 4, 2009·NeuroImage·Douglas N Greve, Bruce Fischl
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Dec 2, 2009·Frontiers in Neuroinformatics·David MeunierEdward T Bullmore
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·P HagmannP E Grant
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xi-Nian ZuoMichael P Milham
Jan 22, 2011·Annals of the New York Academy of Sciences·Olaf Sporns
Mar 17, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Brian Karrer, M E J Newman
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Danielle S BassettScott T Grafton
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Sep 13, 2011·PloS One·Davide ImperatiMichael P Milham
Apr 3, 2012·Scientific Reports·Andrea Lancichinetti, Santo Fortunato
Apr 14, 2012·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Oct 23, 2012·Frontiers in Neuroscience·Kate Brody NoonerMichael P Milham
Jun 1, 2013·Nature Methods·Olaf Sporns
Dec 18, 2013·Developmental Cognitive Neuroscience·Miao CaoYong He
Mar 7, 2014·Frontiers in Neuroinformatics·Eleftherios GaryfallidisUNKNOWN Dipy Contributors
Jun 21, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andreas B StorsveKristine B Walhovd
Sep 18, 2014·Nature Communications·Jason D YeatmanAviv A Mezer
Nov 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Micaela Y ChanGagan S Wig
Jun 19, 2015·Neuron·Bratislav MišićOlaf Sporns
May 1, 2014·Journal of Statistical Mechanics : Theory and Experiment·Xiaoran YanYaojia Zhu
Sep 24, 2015·Annual Review of Psychology·Olaf Sporns, Richard F Betzel
Oct 3, 2015·NeuroImage·Richard F BetzelOlaf Sporns
Jun 17, 2016·Nature Communications·M E J Newman, Aaron Clauset
Jul 30, 2016·Brain Structure & Function·Kathy L RuddyRichard G Carson
Sep 27, 2016·NeuroImage·James A RobertsMichael Breakspear
Nov 21, 2016·Trends in Cognitive Sciences·Xi-Nian ZuoMichael P Milham
Feb 24, 2017·Nature Neuroscience·Danielle S Bassett, Olaf Sporns

❮ Previous
Next ❯

Citations

Sep 13, 2019·Stroke; a Journal of Cerebral Circulation·Sofia Ira KtenaNatalia S Rost
Nov 25, 2019·Brain Structure & Function·Joshua Faskowitz, Olaf Sporns
Jun 17, 2020·Nature Communications·Andrew C MurphyDanielle S Bassett
Nov 17, 2020·Network Neuroscience·Shubhankar P PatankarDanielle S Bassett
Mar 4, 2020·NeuroImage·Richard F BetzelDaniel P Kennedy
Nov 5, 2020·Journal of Neural Engineering·Juliana Gonzalez-AstudilloFabrizio De Vico Fallani
May 26, 2020·NeuroImage·Maria Grazia PuxedduOlaf Sporns
Aug 9, 2019·Journal of Neuroscience Methods·Kleber NevesBruno Mota
Aug 1, 2021·Human Brain Mapping·Riccardo IandoloMichela Chiappalone
Sep 4, 2021·NeuroImage·Vincent BazinetBratislav Misic

❮ Previous
Next ❯

Software Mentioned

Dipy
WSBM
ANTs SyN
eddy
FSL
FreeSurfer
Brain Connectivity Toolbox
correct

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.