Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jagadeesh Kalepu, Lukasz T Pilarski

Abstract

Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of the literature, including the metal catalysts, transformations explored so far and specific insights from mechanistic studies.

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Citations

May 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui LiuShi-Yong Liu
Oct 3, 2020·Chemical Communications : Chem Comm·Naoyuki ShimadaKazuishi Makino
Jan 20, 2021·Organic Letters·Ravichandran Logeswaran, Masilamani Jeganmohan
May 27, 2021·The Journal of Organic Chemistry·Muniyappa Vijaykumar, Benudhar Punji
Sep 5, 2019·The Journal of Organic Chemistry·Danilo Pereira de Sant'AnaRenata Marcia de Figueiredo
Oct 8, 2021·Chemical Reviews·Shubhankar Kumar BoseTodd B Marder

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Methods Mentioned

BETA
amidation

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