Well-being, psychosocial factors, and side-effects among heroin-dependent inpatients after detoxification using buprenorphine versus clonidine

Addictive Behaviors
Alexander M PonizovskyPaula Rosca

Abstract

Previous studies comparing buprenorphine and clonidine provided little information about subjective factors associated with the effective management of opioid withdrawal. This study sought to compare detoxification programs using these medications with regard to side-effects and related distress, general well-being, perceived self-efficacy and social support. A total of 200 treatment-seeking heroin-dependent patients, aged 18-50, were randomly assigned to buprenorphine or clonidine inpatient withdrawal treatments over 10days followed by 11days of relapse prevention measures. A semi-structured interview and a battery of self-rating scales assessing parameters of the interest were administered to the patients who completed the 10-day detoxification protocol with buprenorphine (n=90) and clonidine (n=50). Chi-square statistics and analysis of covariance were performed to examine between-group differences. Compared with patients treated with clonidine, patients who received buprenorphine developed significantly less side-effects and related distress, and had higher senses of well-being, self-efficacy and social support. The findings suggest that buprenorphine is preferable for inpatient detoxification due to its side-effects profil...Continue Reading

References

May 1, 1990·Journal of General Internal Medicine·M D Stein
Jan 1, 1988·The International Journal of Social Psychiatry·G BandyopadhyayG Sen
Mar 1, 1986·Journal of Health and Social Behavior·E Wethington, R C Kessler
Jan 1, 1985·Annual Review of Psychology·R C KesslerC B Wortman
Oct 1, 1994·Drug and Alcohol Dependence·L J CheskinR E Johnson
Sep 1, 1994·Journal of Health and Social Behavior·R J Turner, F Marino
Aug 18, 1994·The New England Journal of Medicine·P G O'ConnorR S Schottenfeld
Jan 1, 1997·Archives of General Psychiatry·R K BroonerG E Bigelow
May 26, 1997·Archives of Internal Medicine·J M LiebschutzJ H Samet
Oct 6, 1997·Annals of Internal Medicine·P G O'ConnorB J Rounsaville
Nov 18, 1997·Drug and Alcohol Dependence·S Darke, J Ross
Apr 3, 1999·Annals of Internal Medicine·K A Sporer
Jul 6, 2000·Annals of Internal Medicine·P G O'Connor, D A Fiellin
Sep 11, 2002·Journal of Substance Abuse Treatment·Walter Ling, David Smith
Oct 24, 2002·Journal of Substance Abuse Treatment·Bethany A DiPaulaCecilia Tang
Dec 6, 2002·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Michael I. FingerhoodDonald R. Jasinski
Jul 31, 2003·Scandinavian Journal of Psychology·Erik SkaretMagne Raadal
Aug 28, 2004·Comprehensive Psychiatry·Alexander PonizovskyItzhak Levav
Feb 19, 2005·Addictive Behaviors·Erol DigiustoUNKNOWN NEPOD Research Group
Jun 1, 2005·TheScientificWorldJournal·Salvatore M GiacomuzziAlexander Vigl
Jun 24, 2008·Science & Practice Perspectives·Thomas R Kosten, Tony P George

❮ Previous
Next ❯

Citations

Nov 9, 2010·European Journal of Clinical Pharmacology·Alexander M PonizovskyNathan I Cherny
Nov 14, 2008·Journal of Substance Abuse Treatment·Gayle RidgeJohn Strang
May 8, 2007·Journal of Substance Abuse Treatment·Gregory S BrighamAlvin Pelt
Aug 23, 2011·The American Journal of Drug and Alcohol Abuse·Sudie E BackWalter Ling
Nov 21, 2009·Clinical Psychology Review·Jennifer C VeilleuxAdrienne J Heinz
Feb 22, 2017·The Cochrane Database of Systematic Reviews·Linda GowingDalitso Mbewe
Sep 25, 2007·The American Journal of Drug and Alcohol Abuse·Alexander M Ponizovsky, Alexander Grinshpoon
May 17, 2019·Oxidative Medicine and Cellular Longevity·Christonikos LeventelisDemetrios Kouretas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.