Well-tolerated portal hypertension and favorable prognosis in adult patients with extrahepatic portal vein obstruction in Japan

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Tadashi SekimotoOsamu Yokosuka

Abstract

To evaluate the clinical features and prognoses in adult patients with extrahepatic portal vein obstruction (EHO) from the aspect of portal hypertension during the last 20 years in Japan. There were 40 EHO patients (aged 21-77 years; mean ± standard deviation [SD], 54.6 ± 15.0). Clinical findings and prognoses were examined retrospectively during the median observation period of 71.6 months. Twenty-two patients (55%) showed positive signs of portal hypertension; 18 with esophageal varices (F0, one; F1, eight; F2, nine), two with gastric varices (F1, one; F2, one) and seven with mild ascites. Multivariate analysis showed that platelet count and spleen size were significant factors for the presence of gastroesophageal varices, with odds ratios of 0.989 (95% confidence interval [CI], 0.980-0.997; P = 0.011) for platelet count and 1.003 (95% CI, 1.001-1.005; P = 0.003) for spleen size. Ten of 20 patients with gastroesophageal varices received primary prophylaxis and only one patient (10%) showed variceal recurrence. The cumulative overall survival rate was 100% at 1 year, 94.2% at 3-7 years and 68.7% at 10 years. The cumulative survival rates did not differ between the patients with and without gastroesophageal varices, with and wi...Continue Reading

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Citations

Apr 5, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Satoko OhfujiYosikazu Nakamura
Oct 5, 2019·European Journal of Gastroenterology & Hepatology·Mirjam GerwingMichael Köhler
Jan 7, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·UNKNOWN Working Subgroup for Clinical Practice Guideline for Aberrant Portal Hemodynamics*,**

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