Wernicke's encephalopathy in advanced gastric cancer.

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Eun Suk JungSun Young Rha

Abstract

With their prolonged survival and malnutrition, cancer patients, and especially gastrointestinal (GI) tract cancer patients, can develop Wernicke's encephalopathy (WE). The aim of this study is to remind physicians of the importance of WE and prompt management in patients with GI tract cancer. This study is a retrospective review of 2 cases of WE in advanced gastric cancer (AGC) patients, and we review the literature for cases of GI tract cancer related to WE. A 48-year-old female with AGC presented dizziness and diplopia for 5 days and a 20 kg weight loss. Neurologic exam showed nystagmus and gaze disturbance. Her symptoms improved after daily parenteral injection of thiamine 100 mg for 17 days. A 58-year-old female with AGC presented with sudden disorientation, confusion and 15 kg weight loss. Neurologic exam showed gaze limitation and mild ataxia. Despite daily parenteral injection of thiamine 100 mg for 4 days, she died 5 days after the onset of neurologic symptoms. Combining the cases noted in the literature review with our 2 cases, the 7 gastric cancer cases and 2 colorectal cancer cases related to WE showed similar clinical characteristics; 1) a history of long-period malnutrition and weight loss, 2) relatively typical n...Continue Reading

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Citations

Jan 26, 2016·The Korean Journal of Internal Medicine·Ju Hyun SeoYoon Ho Ko
Dec 6, 2018·Revista da Associação Médica Brasileira·João Paulo de Vasconcelos LeitãoFernando Barroso Duarte
Dec 2, 2020·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Zining LiuZeyang Chen
Feb 13, 2021·Annals of the New York Academy of Sciences·Filomena GomesPhilip R Fischer

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