West Nile virus is neutralized by HOCl-modified human serum albumin that binds to domain III of the viral envelope protein E

Virology
Markus VossmannMichael Schreiber

Abstract

The outbreaks of West Nile virus (WNV), an emerging flavivirus recently implicated in outbreaks of fatal encephalitis, necessitate the development of effective anti-WNV drugs. In this study, it is demonstrated that human serum albumin is transformed into a WNV antiviral substance by hypochlorite (HOCl) modification. The HOCl-modified albumin efficiently neutralized WNV in vitro (EC50=300 nM) and showed binding to a recombinant protein, representing the domain III of the WNV external envelope E glycoprotein.

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Citations

Jan 11, 2012·Molecular Aspects of Medicine·Gabriella FanaliPaolo Ascenzi
Dec 18, 2009·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Dec 18, 2014·Nature Communications·Alexandra MüllerLars Ingo Ole Leichert
Jun 8, 2010·BMC Research Notes·Svenja PolzerMichael Schreiber
Jul 15, 2020·Cellular and Molecular Life Sciences : CMLS·Agnes Ulfig, Lars I Leichert

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