Western diet feeding influences gut microbiota profiles in apoE knockout mice

Lipids in Health and Disease
Baoning LiuEnqi Liu

Abstract

Gut microbiota plays an important role in many metabolic diseases such as diabetes and atherosclerosis. Apolipoprotein E (apoE) knock-out (KO) mice are frequently used for the study of hyperlipidemia and atherosclerosis. However, it is unknown whether apoE KO mice have altered gut microbiota when challenged with a Western diet. In the current study, we assessed the gut microbiota profiling of apoE KO mice and compared with wild-type mice fed either a normal chow or Western diet for 12 weeks using 16S pyrosequencing. On a western diet, the gut microbiota diversity was significantly decreased in apoE KO mice compared with wild type (WT) mice. Firmicutes and Erysipelotrichaceae were significantly increased in WT mice but Erysipelotrichaceae was unchanged in apoE KO mice on a Western diet. The weighted UniFrac principal coordinate analysis exhibited clear separation between WT and apoE KO mice on the first vector (58.6%) with significant changes of two dominant phyla (Bacteroidetes and Firmicutes) and seven dominant families (Porphyromonadaceae, Lachnospiraceae, Ruminococcaceae, Desulfovibrionaceae, Helicobacteraceae, Erysipelotrichaceae and Veillonellaceae). Lachnospiraceae was significantly enriched in apoE KO mice on a Western d...Continue Reading

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Citations

Jan 3, 2020·Behavioural Pharmacology·Michelle Ren, Shahrdad Lotfipour
Jul 19, 2020·Mucosal Immunology·Sara M ParigiEduardo J Villablanca
Nov 26, 2019·Bioscience of Microbiota, Food and Health·Gizem Özata Uyar, Hilal Yildiran
Aug 13, 2020·Arthritis & Rheumatology·Fanny SaidouneKarim Sacre
Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xin ZhaoQilong Wang
Feb 16, 2021·World Journal of Gastroenterology : WJG·Yan-Dong LiEn-Qi Liu
May 21, 2021·Life Sciences·Kunal DixitSunil Saroj
Apr 1, 2021·Journal of the American Heart Association·Kan HuangGuangqi Chang
May 18, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ran WangChongming Wu
Dec 14, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Djésia ArnoneLaurent Peyrin-Biroulet

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Software Mentioned

Quantitative Insights Into Microbial Ecology ( QIIME
UCLUST
WinROOF
Graphpad Prism
Spot
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