Western diet increases cardiac ceramide content in healthy and hypertrophied hearts

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
T J ButlerA-M Seymour

Abstract

Obesity and cardiac left ventricular hypertrophy (LVH) are recognised independent risk factors in the development of heart failure (HF). However, the combination of these factors may exacerbate the onset of cardiovascular disease by mechanisms as yet unclear. LVH leads to significant cellular remodelling, including alterations in metabolism which may result in an inappropriate accumulation of lipids and eventual lipotoxicity and apoptosis. The aim of the study was to determine the impact of dietary manipulation on cardiac metabolism in the obese and hypertrophied heart. LVH was induced via aortic constriction (AC) in an experimental model of cardiac hypertrophy and animals subjected to 9 weeks of dietary manipulation with either a standard, high fat, or a sucrose containing Western-style diet (SD, HFD and WD, respectively). This latter diet resulted in accelerated weight gain in both LVH/AC and control animals. LVH was greater in AC animals fed a WD, and both control and AC animals from this diet showed a significant reduction in cardiac fatty acid oxidation and increased triacylglycerol content. Ceramide content was significantly increased in the WD groups, with no additional effect of LVH. Comparison with a model of HF induce...Continue Reading

Citations

Sep 25, 2019·Journal of the American Heart Association·Chike C NwabuoRamachandran S Vasan
Jun 21, 2020·Metabolites·Mateusz M Tomczyk, Vernon W Dolinsky
Oct 1, 2020·In Vitro Cellular & Developmental Biology. Animal·Xiaoli ChenLinsheng Shi
Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ivan LiakhAdriana Mika
Jun 25, 2021·Scientific Reports·Loni BerkowitzCarol D Ryff
Aug 27, 2021·Metabolites·Jeffrey PattersonHaiwei Gu

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