Western diet regulates immune status and the response to LPS-driven sepsis independent of diet-associated microbiome

Proceedings of the National Academy of Sciences of the United States of America
Brooke A NapierDenise M Monack

Abstract

Sepsis is a deleterious immune response to infection that leads to organ failure and is the 11th most common cause of death worldwide. Despite plaguing humanity for thousands of years, the host factors that regulate this immunological response and subsequent sepsis severity and outcome are not fully understood. Here we describe how the Western diet (WD), a diet high in fat and sucrose and low in fiber, found rampant in industrialized countries, leads to worse disease and poorer outcomes in an LPS-driven sepsis model in WD-fed mice compared with mice fed standard fiber-rich chow (SC). We find that WD-fed mice have higher baseline inflammation (metaflammation) and signs of sepsis-associated immunoparalysis compared with SC-fed mice. WD mice also have an increased frequency of neutrophils, some with an "aged" phenotype, in the blood during sepsis compared with SC mice. Importantly, we found that the WD-dependent increase in sepsis severity and higher mortality is independent of the microbiome, suggesting that the diet may be directly regulating the innate immune system through an unknown mechanism. Strikingly, we could predict LPS-driven sepsis outcome by tracking specific WD-dependent disease factors (e.g., hypothermia and freque...Continue Reading

References

Feb 12, 1998·Journal of Critical Care·G FriedmanJ L Vincent
Sep 12, 1998·Lancet·J T van DisselM Frölich
Feb 28, 2001·Obesity Research·L RoytblatS Gelman
Sep 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jens M BruunBjørn Richelsen
Jul 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·S B JENSENR J FITZGERALD
Feb 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·M LANDYW L NEWTON
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danielle G SouzaMauro M Teixeira
Sep 15, 2004·Circulation·Husam GhanimParesh Dandona
Feb 9, 2005·The American Journal of Clinical Nutrition·Loren CordainJanette Brand-Miller
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Dec 20, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Patrice D Cani, Nathalie M Delzenne
Oct 18, 2008·Nature Reviews. Immunology·David S Schneider, Janelle S Ayres
Apr 8, 2010·Journal of Gastroenterology and Hepatology·Monique AllmanChantal A Rivera
Jun 3, 2010·The Journal of Clinical Investigation·Kyle J EashDaniel C Link
Aug 14, 2010·Mediators of Inflammation·Rosário Monteiro, Isabel Azevedo
Dec 22, 2010·European Journal of Medical Research·Katarzyna PopkoU Demkow
Jan 10, 2012·Annual Review of Immunology·Janelle S Ayres, David S Schneider
Jan 19, 2012·Nutrients·Marco A R VinoloRui Curi
Feb 14, 2012·Gastroenterology·Swaroop PendyalaPeter R Holt
Mar 1, 2012·Science·Ruslan MedzhitovMiguel P Soares
Mar 1, 2012·The Proceedings of the Nutrition Society·Philip C Calder
Apr 27, 2012·North American Journal of Medical Sciences·Rajeev GoyalMonil Singhai
May 31, 2012·Journal of the American Geriatrics Society·Theodore J IwashynaJeremy M Kahn
Feb 26, 2013·Nature Reviews. Immunology·Elzbieta Kolaczkowska, Paul Kubes
Feb 28, 2013·Critical Care Medicine·David F GaieskiBrendan G Carr
May 28, 2013·Cell·María Casanova-AcebesAndrés Hidalgo
Dec 18, 2013·Current Allergy and Asthma Reports·Arndt ManzelMarkus Kleinewietfeld
Jan 7, 2014·Nature Medicine·Aurélien TrompetteBenjamin J Marsland
Jan 22, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Tzu-Yi ChuangPo-Ren Hsueh
Apr 18, 2014·The Lancet. Respiratory Medicine·Jean-Louis VincentUNKNOWN ICON investigators
Mar 31, 2015·PLoS Pathogens·Ruth J NapierDaniel Kalman
Jun 17, 2015·Scientific Reports·Maja SurbatovicSonja Radakovic
Sep 17, 2015·Nature·Dachuan ZhangPaul S Frenette
Dec 19, 2015·Molecular Nutrition & Food Research·Veronika Maria MüllerHannelore Daniel

❮ Previous
Next ❯

Citations

Aug 8, 2020·Expert Opinion on Therapeutic Targets·Jeremiah StithamBabak Razani
Oct 9, 2019·MBio·Christine M Bassis
Mar 25, 2020·Critical Care : the Official Journal of the Critical Care Forum·Matteo BassettiAndrea Gori
Jan 17, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Redouane RebaiAbdennacer Boudah
Jan 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sahar EshghjooRobert C Alaniz
Feb 13, 2021·Nature Immunology·Robert T Patry, Cathryn R Nagler
Mar 13, 2020·The Journal of Nutritional Biochemistry·Rachel M GolonkaMatam Vijay-Kumar
Aug 20, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Priyankar Dey
Apr 20, 2021·Frontiers in Aging Neuroscience·Angelika Wiȩckowska-GacekUrszula Wojda
Jun 22, 2021·EMBO Molecular Medicine·Simon HirschbergerSimone Kreth
Jul 3, 2021·International Journal of Molecular Sciences·Marcello CandelliFrancesco Franceschi
Jul 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Eréndira Guadalupe Pérez-HernándezJaime Mas-Oliva
Jul 20, 2021·Journal of Inflammation Research·Chang YuXiaoni Kong
Nov 16, 2021·Frontiers in Immunology·Suguru SaitoDerick Okwan-Duodu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved