Western Indian Rural Gut Microbial Diversity in Extreme Prakriti Endo-Phenotypes Reveals Signature Microbes

Frontiers in Microbiology
Nar S ChauhanDebasis Dash

Abstract

Heterogeneity amidst healthy individuals at genomic level is being widely acknowledged. This, in turn, is modulated by differential response to environmental cues and treatment regimens, necessitating the need for stratified/personalized therapy. We intend to understand the molecular determinants of Ayurvedic way (ancient Indian system of medicine) of endo-phenotyping individuals into distinct constitution types termed "Prakriti," which forms the basis of personalized treatment. In this study, we explored and analyzed the healthy human gut microbiome structure within three predominant Prakriti groups from a genetically homogenous cohort to discover differentially abundant taxa, using 16S rRNA gene based microbial community profiling. We found Bacteroidetes and Firmicutes as major gut microbial components in varying composition, albeit with similar trend across Prakriti. Multiple species of the core microbiome showed differential abundance within Prakriti types, with gender specific signature taxons. Our study reveals that despite overall uniform composition of gut microbial community, healthy individuals belonging to different Prakriti groups have enrichment of specific bacteria. It highlights the importance of Prakriti based e...Continue Reading

References

Sep 3, 2008·Microbes and Infection·Maria G Dominguez-Bello, Martin J Blaser
Sep 11, 2008·Journal of Translational Medicine·Bhavana PrasherMitali Mukerji
Apr 9, 2009·Nature Biotechnology·Matthias H TschöpChristopher L Karp
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Karen P ScottHarry J Flint
Aug 17, 2010·Bioinformatics·Robert C Edgar
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shilpi AggarwalMitali Mukerji
Mar 23, 2011·Birth Defects Research. Part C, Embryo Today : Reviews·Eugene Rosenberg, Ilana Zilber-Rosenberg
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Sep 3, 2011·Science·Gary D WuJames D Lewis
Sep 20, 2011·ACS Chemical Biology·Tav Pritesh SethiMitali Mukerji
Oct 19, 2011·Environmental Microbiology·Ashley Shade, Jo Handelsman
Mar 14, 2012·Nature Reviews. Genetics·Ilseung Cho, Martin J Blaser
May 11, 2012·Current Opinion in Gastroenterology·Lindsey G AlbenbergGary D Wu
Jun 8, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L W Parfrey, R Knight
Jun 8, 2012·Science·Henry J Haiser, Peter J Turnbaugh
Jun 8, 2012·Science Translational Medicine·Jeffrey I GordonRuslan M Medzhitov
Jun 12, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Maneesh DaveKevin P Rioux
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Jun 16, 2012·Nature·Tanya YatsunenkoJeffrey I Gordon
Dec 25, 2012·Gut·Venessa EeckhautFilip Van Immerseel
Apr 10, 2013·Trends in Microbiology·J Dennis Fortenberry
Sep 7, 2013·Science·Vanessa K RidauraJeffrey I Gordon
Feb 7, 2014·Journal of Clinical Microbiology·Thomas V SydenhamUlrik S Justesen
May 28, 2014·FEMS Microbiology Reviews·Mirjana Rajilić-Stojanović, Willem M de Vos
Jun 18, 2014·The ISME Journal·A Murat ErenSandra L McLellan
Aug 2, 2014·World Journal of Gastroenterology : WJG·Valentina Taverniti, Simone Guglielmetti
Sep 10, 2014·Standards in Genomic Sciences·Amy S BiddleJeffrey L Blanchard
Oct 23, 2014·Journal of Ayurveda and Integrative Medicine·Harish RottiMarthanda Varma Sankaran Valiathan
Nov 13, 2014·Molecular Microbiology·Darrell W CockburnNicole M Koropatkin
Apr 18, 2015·The ISME Journal·Tracy D AinsworthWilliam Leggat
May 16, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Robert R JenqMarcel R M van den Brink
Jun 7, 2015·Journal of Translational Medicine·Shilpi AggarwalUNKNOWN Indian Genome Variation Consortium

❮ Previous
Next ❯

Citations

May 5, 2018·Environmental Microbiology·Antoine Danchin
Oct 31, 2018·Scientific Data·Ashok Kumar DubeyAnirban Bhaduri
Nov 17, 2020·Frontiers in Microbiology·Monika YadavNar Singh Chauhan
Dec 4, 2020·Medicina·Robert Keith Wallace
Apr 6, 2021·PeerJ. Computer Science·Camila K DiasDaniel K Morais

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

GreenGenes
R
LEfSe
EIGENSOFT
UCLUST
Quantitative Insights into Microbial Ecology ( QIIME )
Vegan
USEARCH
ggplot2
Blast

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved