Wet, volatile, and dry biomarkers of exercise-induced muscle fatigue

BMC Musculoskeletal Disorders
Josef Finsterer, Vivian E Drory

Abstract

The physiological background of exercise-induced muscle fatigue(EIMUF) is only poorly understood. Thus, monitoring of EIMUF by a single or multiple biomarkers(BMs) is under debate. After a systematic literature review 91 papers were included. EIMUF is mainly due to depletion of substrates, increased oxidative stress, muscle membrane depolarisation following potassium depletion, muscle hyperthermia, muscle damage, impaired oxygen supply to the muscle, activation of an inflammatory response, or impaired calcium-handling. Dehydration, hyperammonemia, mitochondrial biogenesis, and genetic responses are also discussed. Since EIMUF is dependent on age, sex, degree of fatigue, type, intensity, and duration of exercise, energy supply during exercise, climate, training status (physical fitness), and health status, BMs currently available for monitoring EIMUF have limited reliability. Generally, wet, volatile, and dry BMs are differentiated. Among dry BMs of EIMUF the most promising include power output measures, electrophysiological measures, cardiologic measures, and questionnaires. Among wet BMs of EIMUF those most applicable include markers of ATP-metabolism, of oxidative stress, muscle damage, and inflammation. VO2-kinetics are used...Continue Reading

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Citations

Dec 20, 2016·Scientific Reports·Nobuhiro MaruyamaYo-Ichi Nabeshima
Feb 2, 2018·Journal of Clinical Medicine·Josef Finsterer, Sinda Zarrouk-Mahjoub
Oct 31, 2017·Research in Sports Medicine·Diego Marqués-JiménezNicolás Terrados
Nov 12, 2019·Frontiers in Genetics·Ana Paula Rennó SierraMaria Fernanda Cury-Boaventura
Sep 25, 2019·Research : a Science Partner Journal·Fidias E Leon-SarmientoZeng Y Wang
Jul 19, 2020·Scientific Reports·Thomas ReichelKarsten Krüger
Jun 3, 2021·International Journal of Environmental Research and Public Health·Sebastian HackerKarsten Krüger

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Methods Mentioned

BETA
biopsy
electrophoresis

Software Mentioned

Ovid
EBSCO
Motion Analysis Corporation

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