Wet wound healing: from laboratory to patients to gene therapy

American Journal of Surgery
Elof Eriksson, Jan Vranckx

Abstract

Wet treatment of wounds has been used as an "irrigation" method since the seventh century. We have developed the concept of an in vivo tissue culture that facilitates wound healing and allows tissue engineering. A transparent, flexible, round chamber provides the wet environment. This system heals clean wounds as fast or faster than any other method, with less scarring. It allows delivery of analgesics, antibiotics, growth factors, growth media, and cells into the chamber, becoming a platform for tissue engineering. Gene therapy of the wound can be done in the chamber with growth factor and other genes. A tetracycline switch allows precise timing and amounts of expression and provides the opportunity for sequential expression of genes delivered at the same time.

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Citations

Oct 29, 2010·Stem Cells and Development·Justin D KleinDario O Fauza
Nov 2, 2005·The Veterinary Clinics of North America. Small Animal Practice·June Hanks, Gary Spodnick
Nov 1, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jan Jeroen VranckxFeng Yao
Aug 12, 2014·BioMed Research International·Najmeh KhanbanhaRassoul Dinarvand
Oct 26, 2016·EBioMedicine·Ru-Lin HuangQingfeng Li
Jan 28, 2006·Cells, Tissues, Organs·Magdalena FossumAgneta Nordenskjöld
Sep 2, 2020·Advances in Wound Care·Kristo Nuutila, Elof Eriksson
May 16, 2006·The Journal of Surgical Research·David C ChenMatthias Stelzner

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