Abstract
Currently there is no cure for severe atopic dermatitis (AD). Wet-wrap therapy (WWT) has also been used to treat pediatric AD and shown a satisfactory effectiveness, but clinical evidence supporting the use of WWT on severe adult AD is still insufficient. Twelve patients (eight men and four women) with severe AD (SCORing Atopic Dermatitis [SCORAD] score ≥ 50) treated between January 2015 and September 2017 in our hospital were included. The patients underwent WWT (daily dose: 15 g halometasone cream+100g Vaseline ointment) twice daily for 2 h/session for 7 days. SCORAD, visual analog scale (VAS) for pruritus, investigator's global assessment (IGA), dermatology life quality index (DLQI) scores and serum cortisol levels were determined before and after the WWT. The patients (mean age: 58.9 ± 18.9 years; range: 27-85 years) had a median disease duration of 27.5 months. After the WWT, the average scores of SCORAD (28.79 ± 5.16 vs. 68.59 ± 8.61, 95%CI: 35.18-44.42), VAS (2.75 ± 0.62 vs. 7.5 ± 1.17, 95%CI: 4.14-5.36), IGA (1.83 ± 0.39 vs. 4.08 ± 0.51, 95%CI: 1.96-2.54), and DQLI score (8.33 ± 1.83 vs. 13.83 ± 2.79, 95%CI: 4.16-6.84) reduced significantly compared with the scores before the WWT (All P < 0.001). However, serum cortisol...Continue Reading
References
Dec 1, 1991·The British Journal of Dermatology·H M GoodyearJ I Harper
Sep 1, 1994·The British Journal of Dermatology·H C WilliamsR A Graham-Brown
May 1, 1994·Clinical and Experimental Dermatology·A Y Finlay, G K Khan
Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology
Sep 6, 2005·Pediatrics·Lawrence A SchachnerUNKNOWN US Tacrolimus Ointment Study Group
Oct 26, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·A P OranjeJ Harper
Oct 26, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·J H LeeD Bang
Apr 25, 2009·Journal of the American Academy of Dermatology·Lucas G BinghamMark D P Davis
Oct 8, 2011·Journal of the American Academy of Dermatology·Tushar S DabadeMark D P Davis
Jan 20, 2012·Pediatric Dermatology·Arjan C A Devillers, Arnold P Oranje
Apr 5, 2014·Journal of the American Academy of Dermatology·Sherief R JanmohamedFlora B de Waard-van der Spek
Jul 16, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Noreen Heer NicolMary D Klinnert
Dec 9, 2014·The Journal of Allergy and Clinical Immunology·Jennifer D HamiltonEmma Guttman-Yassky
Mar 24, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A WollenbergUNKNOWN European Task Force on Atopic Dermatitis/EADV Eczema Task Force
Aug 9, 2016·The Journal of Allergy and Clinical Immunology·Thomas WerfelCezmi A Akdis
Nov 20, 2016·The British Journal of Dermatology·G González-LópezP Herranz-Pinto
Feb 7, 2017·Expert Review of Clinical Immunology·Magdalena Kraft, Margitta Worm