Apr 23, 2020

Lymph Node Morphology in Stage II Colorectal Cancer

BioRxiv : the Preprint Server for Biology
Annabelle GreenwoodK. Danielson

Abstract

BACKGROUND: Colorectal cancer is one of the leading causes of cancer-associated morbidity and mortality worldwide. The local anti-tumour immune response is particularly important for patients with stage II where the tumour-draining lymph nodes have not yet succumbed to tumour spread. The lymph nodes allow for the expansion and release of B cell compartments such as primary follicles and germinal centres. A variation in this anti-tumour immune response may influence the observed clinical heterogeneity in stage II patients. AIM: The aim of this study was to explore tumour-draining lymph node histomorphological changes and tumour pathological risk factors including the immunomodulatory microRNA-21 (miR-21) in a small cohort of stage II CRC. METHODS: A total of 23 stage II colorectal cancer patients were included. Tumour and normal mucosa samples were analysed for miR-21 expression levels and B-cell compartments were quantified from Haematoxylin and Eosin slides of lymph nodes. These measures were compared to clinicopathological risk factors such as perforation, bowel obstruction, T4 stage and high-grade. RESULTS: We observed greater follicle density in patients with a lower tumour T stage and higher germinal centre density in pati...Continue Reading

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Mentioned in this Paper

Biological Markers
Classification
Metagenome
Weighing Patient
Evaluation
Cocaine
Microbial
Analysis
Shotgun Sequencing
GPER protein, human

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