What - if any - is the role of adrenergic mechanisms in histamine release from mast cells?

Agents and Actions
P E Alm, G D Bloom

Abstract

The effects of catecholamines on histamine release from rat peritoneal mast cells, was studied in an in vitro system. It was found that norepinephrine (10(-5)-101(-3) M) exerts a significant, dose related, repressive effect on compound 48/80-induced histamine release. This effect is greatly potentiated by beta-antagonists and is noticeable throughout the concentration range 10(-11)-10(-3) M norepinephrine. Phentolamine diminishes the repressive effect that norepinephrine shows at 10(-5) M. Norepinephrine (10(-5) M) totally inhibits the progressive histamine release induced by both compound 48/80 and strontium (10 muM) in non-Ca2+-depleted cells. The release that is dependent on extracellular calcium is inhibited by norepinephrine. The repressive effect of norepinephrine at 10(-3) is counteracted by 5.6 mM D-glucose, 2-deoxyglucose abolishes this effect. The repression of histamine release by 10(-5) M norepinephrine is not influenced by D-glucose. These results suggest that the effects on histamine release, observed within a low concentration range of norepinephrine (less than 10(-3) M), may be due to alpha-adrenoreceptor mechanisms and an interference in transmembrane calcium transport. Our data further suggest that norepinephr...Continue Reading

References

Jan 1, 1975·International Archives of Allergy and Applied Immunology·B Diamant
Jan 1, 1975·International Archives of Allergy and Applied Immunology·B Diamant, S A Patkar
Sep 1, 1977·The Journal of Physiology·J C Foreman
Sep 1, 1977·The Journal of Physiology·J C ForemanJ L Mongar
Jan 1, 1979·International Archives of Allergy and Applied Immunology·P E Alm, G D Bloom
Aug 1, 1972·The Journal of Physiology·J C Foreman, J L Mongar
Nov 1, 1968·British Journal of Pharmacology·W W Douglas
Jan 1, 1981·International Archives of Allergy and Applied Immunology·P E Alm, G D Bloom

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.