Abstract
The effects of catecholamines on histamine release from rat peritoneal mast cells, was studied in an in vitro system. It was found that norepinephrine (10(-5)-101(-3) M) exerts a significant, dose related, repressive effect on compound 48/80-induced histamine release. This effect is greatly potentiated by beta-antagonists and is noticeable throughout the concentration range 10(-11)-10(-3) M norepinephrine. Phentolamine diminishes the repressive effect that norepinephrine shows at 10(-5) M. Norepinephrine (10(-5) M) totally inhibits the progressive histamine release induced by both compound 48/80 and strontium (10 muM) in non-Ca2+-depleted cells. The release that is dependent on extracellular calcium is inhibited by norepinephrine. The repressive effect of norepinephrine at 10(-3) is counteracted by 5.6 mM D-glucose, 2-deoxyglucose abolishes this effect. The repression of histamine release by 10(-5) M norepinephrine is not influenced by D-glucose. These results suggest that the effects on histamine release, observed within a low concentration range of norepinephrine (less than 10(-3) M), may be due to alpha-adrenoreceptor mechanisms and an interference in transmembrane calcium transport. Our data further suggest that norepinephr...Continue Reading
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