What are the Evolutionary Origins of Mitochondria? A Complex Network Approach

PloS One
Daniel S CarvalhoCharbel N El-Hani

Abstract

Mitochondria originated endosymbiotically from an Alphaproteobacteria-like ancestor. However, it is still uncertain which extant group of Alphaproteobacteria is phylogenetically closer to the mitochondrial ancestor. The proposed groups comprise the order Rickettsiales, the family Rhodospirillaceae, and the genus Rickettsia. In this study, we apply a new complex network approach to investigate the evolutionary origins of mitochondria, analyzing protein sequences modules in a critical network obtained through a critical similarity threshold between the studied sequences. The dataset included three ATP synthase subunits (4, 6, and 9) and its alphaproteobacterial homologs (b, a, and c). In all the subunits, the results gave no support to the hypothesis that Rickettsiales are closely related to the mitochondrial ancestor. Our findings support the hypothesis that mitochondria share a common ancestor with a clade containing all Alphaproteobacteria orders, except Rickettsiales.

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Citations

Feb 21, 2019·Genome Biology and Evolution·Dennifier Costa Brandão CruzPhellippe Arthur Santos Marbach
Jun 4, 2020·Biochemical Society Transactions·Luis Alberto Luévano-Martínez, Anna L Duncan
Nov 28, 2017·Molecular Microbiology·Christian OttenJeanne Salje
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Feb 15, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Liwen LinTodd V Brennan
Jan 31, 2020·Intensive Care Medicine·Nishkantha ArulkumaranAndrew Conway Morris

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Software Mentioned

BLAST
NGA
GePhi

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