What are the long-term benefits of weight reducing diets in adults? A systematic review of randomized controlled trials

Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association
A AvenellW C S Smith

Abstract

Evidence is needed for the best long-term diet for weight loss, and improvement in cardiac risk and disease in obese adults. We systematically reviewed randomized controlled trials (RCTs) in any language. We searched 13 databases and handsearched journals. Trials lasted 1 year or more. One investigator extracted the data and a second checked data extraction. Trial quality was assessed. Low fat diets (LFDs) produced significant weight losses up to 36 months (-3.55 kg; 95% CI, -4.54 to -2.55 kg). Blood pressure, lipids and fasting plasma glucose improved with these diets after 12 months. Four studies found that LFDs may prevent type 2 diabetes and reduce antihypertensive medication for up to 3 years. A very low calorie diet (VLCD, < 4.2 MJ day(-1)) was associated with the most weight loss after 12 months (-13.40 kg; 95% CI, -18.43 to -8.37 kg) in one small study with beneficial effects on asthma. There was no evidence that low carbohydrate protein sparing modified fasts (PSMFs) were associated with greater long-term weight loss than low calorie diets (LCDs, 4.2-6.7 MJ day(-1)) or VLCDs. PSMFs were, however, associated with greater lowering of fasting plasma glucose and HbA1c than LCDs. Little evidence supports the use of diets ot...Continue Reading

References

Aug 15, 1991·American Journal of Epidemiology·P L CannerF J Hooper
Apr 15, 1991·Annals of Internal Medicine·S Wassertheil-SmollerH G Langford
Jan 1, 1990·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·R W JefferyT L Schmid
Feb 1, 1990·The American Journal of Clinical Nutrition·J L ForsterP Pirie
May 1, 1989·The American Journal of Clinical Nutrition·K N PavlouW P Steffee
Dec 1, 1988·Journal of Consulting and Clinical Psychology·T A WaddenJ Liebschutz
Jul 1, 1988·The American Journal of Cardiology·S P FortmannP D Wood
Aug 1, 1986·Journal of Consulting and Clinical Psychology·T A Wadden, A J Stunkard
Jan 1, 1984·Behaviour Research and Therapy·R R WingR Koeske
Nov 12, 1994·BMJ : British Medical Journal·K DickersinC Lefebvre
Aug 1, 1994·American Journal of Hypertension·G Y HoH Langford
Dec 1, 1993·American Journal of Hypertension·L ThalerH G Langford
May 1, 1993·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·F de WaardS van Waveren
Aug 1, 1996·Journal of Consulting and Clinical Psychology·G D FosterR A Vogt
Aug 1, 1996·American Journal of Hypertension·S Julius
Aug 1, 1996·American Journal of Hypertension·D W Jones
Jan 1, 1997·Journal of the American Dietetic Association·J E PritchardJ D Wark
Nov 22, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J S TorgersonL Sjöström
Oct 2, 1998·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·M KiernanJ D Killen
Mar 17, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J S TorgersonL Sjöström
Dec 9, 1995·American Journal of Health Promotion : AJHP·M ShahA Garg
Jul 9, 1999·Journal of Epidemiology and Community Health·D A PritchardF Taba
Nov 5, 1999·JAMA : the Journal of the American Medical Association·A MustW H Dietz
Nov 5, 1999·JAMA : the Journal of the American Medical Association·D B AllisonT B VanItallie
Nov 26, 1999·Journal of the American Dietetic Association·B A SwinburnM R Wilson
Mar 24, 2000·BMJ : British Medical Journal·B Stenius-AarnialaP Mustajoki
Jun 29, 2000·The American Journal of Clinical Nutrition·P SimonenT A Miettinen

❮ Previous
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Citations

Mar 23, 2012·Obesity Surgery·N NguyenF Favretti
Mar 28, 2008·Current Diabetes Reports·Matthew Gilbert, Richard E Pratley
Sep 1, 2007·Current Treatment Options in Cardiovascular Medicine·Harold BaysJ Michael González-Campoy
Feb 16, 2010·Diabetes & Metabolism·F AndreelliG Mithieux
Mar 17, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L D HoweD A Lawlor
Oct 26, 2010·European Heart Journal·Emanuela FalaschettiJohn E Deanfield
Dec 20, 2008·Human Reproduction·M MetwallyW L Ledger
Oct 1, 2010·Diabetes, Obesity & Metabolism·P A Dyson
Aug 27, 2010·Health Promotion International·Theo van AchterbergHub C H Wollersheim
Mar 3, 2009·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jason LillisAkihiko Masuda
Jun 26, 2012·International Review of Psychiatry·Ann O Scheimann
Jul 17, 2015·Obesity·Mirjam Langeveld, J Hans DeVries
Dec 2, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Andrew J TeichtahlFlavia M Cicuttini
Apr 24, 2013·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Omar Al-NozhaMohamed Fath El-Bab
Dec 26, 2012·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·UNKNOWN ASMBS Clinical Issues Committee
Jul 31, 2013·Australian and New Zealand Journal of Public Health·Katina D'OniseSandra K Campbell
Dec 25, 2007·Journal of the American Dietetic Association·Julienne K KirkKaren L Margolis
Mar 14, 2007·Appetite·Junilla K LarsenRutger C M E Engels
Oct 26, 2005·Neurologic Clinics·Conrad Iber
Jun 25, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·R L KennedyH R Farshchi
Feb 24, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J P H Wilding
May 15, 2008·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·R BarrattH Truby
Jun 23, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A Astrup
Nov 12, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·J TolC Veenhof
Dec 21, 2013·International Journal of Clinical Practice·M BobanL Boban
Oct 12, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·J KhooM Cheong
Apr 14, 2015·Gastroenterology·Eduardo Vilar-GomezManuel Romero-Gomez
Jul 23, 2016·Archives of Biochemistry and Biophysics·Marieke G SchoonemanMaarten R Soeters
May 19, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·E ArrebolaL M Bermejo

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