What are the neural correlates of meta-cognition and anosognosia in Alzheimer's disease? A systematic review.

Neurobiology of Aging
Brendan HallamJonathan Huntley

Abstract

Awareness of one's own cognitive processes (metacognition) or of one's own illness or deficits (anosognosia) can be impaired in people with Alzheimer's disease (AD). The neural correlates of anosognosia within AD remain inconclusive. Understanding anosognosia is of importance because of its impact on carer burden and increased institutionalization. A systematic review of structural and functional neuroimaging studies was conducted to identify specific brain regions associated with anosognosia within AD. Thirty-two studies were included in the systematic review. Reduced gray matter density, cerebral blood flow, and hypometabolism in 8 key regions were significantly associated with increased anosognosia scores in people with AD. The most frequently associated regions were the inferior frontal gyrus, anterior cingulate cortex, and medial temporal lobe. Other key regions include the superior frontal gyrus, medial frontal gyrus, orbitofrontal cortex, posterior cingulate cortex, and the insula. Identifying brain regions associated with anosognosia can aid understanding and identification of anosognosia in people with AD and potentially facilitate improvements in care.

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Citations

Feb 10, 2021·Neurobiology of Aging·Jaime D MondragónUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 1, 2021·JAD Reports·Marina Ávila-VillanuevaMiguel A Fernández-Blázquez
Jul 13, 2021·Journal of Alzheimer's Disease : JAD·Shanshan ChenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 19, 2021·Neuropsychologia·Candace M van der SteltPeter E Turkeltaub

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imaging techniques

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