What are the next breakthroughs in the management of acute intracerebral hemorrhage?

International Journal of Stroke : Official Journal of the International Stroke Society
Kazunori ToyodaShoichiro Sato

Abstract

The impact of acute therapy for intracerebral hemorrhage is far behind that for acute ischemic stroke. Potential breakthroughs in the management of acute intracerebral hemorrhage are presented. To prevent early hematoma growth, acute blood pressure lowering, emergent hemostatic therapy, and minimally invasive surgery with topical thrombolysis have been attempted. Anti-inflammatory and neuroprotective pharmacotherapies may attenuate perihematomal edema as a surrogate marker for the inflammatory response and improve clinical outcomes after intracerebral hemorrhage. Hyperacute modification of vital parameters, early seizure control, early rehabilitation, and neuroregenerative therapy are other promising strategies in the foreseeable future.

References

May 16, 2008·The New England Journal of Medicine·Stephan A MayerUNKNOWN FAST Trial Investigators
Feb 4, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Martin EbingerUNKNOWN STEMO-Consortium
May 30, 2013·The New England Journal of Medicine·Craig S AndersonUNKNOWN INTERACT2 Investigators
Dec 12, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takuma WakaiPak H Chan
Jun 23, 2015·The New England Journal of Medicine·Charles V PollackJeffrey I Weitz
Oct 20, 2015·Current Treatment Options in Neurology·Shoichiro SatoCraig S Anderson
Nov 13, 2015·The New England Journal of Medicine·Deborah M SiegalMark A Crowther

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Citations

Apr 1, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Yasuteru InoueKazunori Toyoda
Nov 14, 2018·Annals of Neurology·Kazunori ToyodaUNKNOWN ATACH-2 Trial Investigators

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Clinical Trials Mentioned

NCT01176565
NCT01702636
NCT01827046
NCT00784134

Software Mentioned

INTERACT2

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