PMID: 12763123May 24, 2003Paper

What are the realistic expectations of tocolytics?

BJOG : an International Journal of Obstetrics and Gynaecology
Graeme N Smith

Abstract

Preterm birth, the leading cause of neonatal morbidity and mortality worldwide, is a major public health problem in terms of loss of life, long term disability (e.g. cerebral palsy, chronic lung disease), and health-care costs. The outcome of preterm infants is directly related to the gestational age at delivery. The goal of tocolytic therapy is to reduce neonatal morbidity and mortality by delaying delivery, to allow for the administration of corticosteroids and/or the safe transfer to a tertiary-care centre. However, currently available tocolytics in Canada (ritodrine, indomethacin, calcium antagonists, magnesium sulphate) have poor efficacy, have not been shown to increase the completion of a course of corticosteroids, are potentially associated with significant maternal/fetal side effects, and most importantly, have not been shown to improve neonatal outcomes. At the Canadian Tocolysis Consensus Conference, there was general agreement that recommendations should be based on good quality research evidence, particularly that of randomised clinical trials when available. It was concluded that there is little evidence to support the use of any of the currently available tocolytics; tocolytic use has not been associated with imp...Continue Reading

Associated Clinical Trials

Nov 25, 2020·Ethem Unal, M.D., PhD, Associate Prof of Surgery & Surgic

References

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Citations

Dec 4, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Anna KlukovitsRóbert Gáspár
Oct 21, 2009·Paediatric and Perinatal Epidemiology·Marc J N C KeirseHugo Devlieger
Oct 15, 2011·The Journal of Obstetrics and Gynaecology Research·Christopher P Plummer
Nov 9, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jérémy TerrienGuy Germain
Jul 3, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Nagihan KarahanAli Gürbüz
Feb 5, 2005·Seminars in Fetal & Neonatal Medicine·Shi Wu WenMark Walker
Aug 26, 2014·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Kathleen McCubbinChristian Vaillancourt
Sep 8, 2010·American Journal of Obstetrics and Gynecology·Graeme N SmithUNKNOWN Canadian Preterm Labor Nitroglycerin Trial Group
Jan 24, 2007·American Journal of Obstetrics and Gynecology·Graeme N SmithUNKNOWN Canadian Preterm Labour Nitroglycerin Trial Group
Jul 9, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·L A A KolléeUNKNOWN MOSAIC Research group
Jan 13, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·D A PaulG Colmorgen

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