PMID: 16502647Mar 1, 2006Paper

What are the relevant parameters for the geometrical optimization of an implantable bioartificial pancreas?

Journal of Biomechanical Engineering
Jean-Luc Dulong, Cécile Legallais

Abstract

A sphere within a cylinder representing the islet encapsulated in a hollow fiber can model an implantable bioartificial pancreas. Based on a finite element model for insulin response to a glucose load in the presence of various oxygen supplies, the present study aimed at pointing out the major parameters influencing this secretion. The computational results treated with the Taguchi method clearly demonstrated that geometrical parameters (fiber length and islet density) should be precisely optimized for an enhanced insulin response. This requires the collection of more relevant experimental data concerning the islet oxygen consumption. Moreover, the relative errors on glucose consumption or insulin secretion by the islets do not seem to affect the whole optimization process, which should focus on the oxygen supply to islets.

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Citations

Jun 23, 2011·Theoretical Biology & Medical Modelling·Peter Buchwald
Mar 4, 2014·Advanced Drug Delivery Reviews·Clark K Colton
Aug 7, 2013·Advanced Drug Delivery Reviews·David W Scharp, Piero Marchetti
Sep 2, 2015·Biochemical Pharmacology·Veronica IacovacciPaolo Dario
Jan 30, 2016·Journal of Diabetes Research·A Rodriguez-BrotonsE Maillard
Jul 8, 2014·Biomaterials·Lucas S KumosaDavid A Gough
Oct 6, 2010·Journal of Diabetes Science and Technology·Jaime A GiraldoCherie L Stabler
Aug 10, 2006·Biotechnology and Bioengineering·Jean-Luc Dulong, Cécile Legallais
Jun 23, 2020·Macromolecular Bioscience·Katarzyna SkrzypekDimitrios Stamatialis

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